MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status
MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status
复制标题
MAPK 不参与雷公藤甲素诱导的具有不同 p53 状态的前列腺癌细胞系的细胞生长抑制和细胞凋亡
DOI：
10.1055/s-0030-1250076
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发表时间：
2011-01-01
期刊：
影响因子：
2.7
通讯作者：
Yang, Ling
中科院分区：
文献类型：
--
作者：
Li, Wei;Liu, Yong;Yang, Ling
Triptolide showed excellent antitumor activity against several solid tumors. However, its mechanism has not been fully understood. To further elucidate it, the effects of mitogen activated protein kinases (MAPKs) on the activity of triptolide towards prostate cancer cell lines were investigated in the present study using both LNCaP (p53 positive and androgen-dependent) and PC-3 (p53 deficient and androgen-independent) cells. Our results showed that triptolide exerted potent growth inhibitory and apoptotic effects on both cell lines, and the effects were independent of the expression of p53. Although upregulation of ERK and JNK phosphorylation was observed after the triptolide treatment, the results with inhibitors showed that these MAPKs were not involved in the mechanism of triptolide activity in human prostate cancer cell lines with different p53 status.
