Biomedical surface analysis: Evolution and future directions (Review).
Biomedical surface analysis: Evolution and future directions (Review).
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DOI：
10.1116/1.4982169
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发表时间：
2017-04-24
期刊：
影响因子：
2.1
通讯作者：
Castner DG
中科院分区：
文献类型：
--
作者：
Castner DG
本文综述了过去30-40年来生物医学表面分析的一些主要进展。从对均匀表面的单一技术分析开始，它已经发展成为一种互补的多技术方法，用于获得生物医学界感兴趣的广泛表面和界面的详细，全面的信息。每种表面分析技术都取得了重大进展，以及如何将这些技术结合起来提供有关生物表面和界面的详细信息。这些进步的驱动力是生物材料的表面是生物环境和生物材料之间的界面，因此，需要开发最先进的仪器、实验方案和数据分析方法，以便确定生物医学设备的详细表面结构和组成，并与它们的生物性能相关。这些进展的例子，以及未来发展的领域，描述了固定化蛋白质，复杂生物医学表面，纳米颗粒和生物材料的2D/3D成像。
This review describes some of the major advances made in biomedical surface analysis over the past 30–40 years. Starting from a single technique analysis of homogeneous surfaces, it has been developed into a complementary, multitechnique approach for obtaining detailed, comprehensive information about a wide range of surfaces and interfaces of interest to the biomedical community. Significant advances have been made in each surface analysis technique, as well as how the techniques are combined to provide detailed information about biological surfaces and interfaces. The driving force for these advances has been that the surface of a biomaterial is the interface between the biological environment and the biomaterial, and so, the state-of-the-art in instrumentation, experimental protocols, and data analysis methods need to be developed so that the detailed surface structure and composition of biomedical devices can be determined and related to their biological performance. Examples of these advances, as well as areas for future developments, are described for immobilized proteins, complex biomedical surfaces, nanoparticles, and 2D/3D imaging of biological materials.