Diagnostic Efficacy of 18F-FDG PET/MRI in Peripheral Nerve Injury Models
Diagnostic Efficacy of 18F-FDG PET/MRI in Peripheral Nerve Injury Models
复制标题
DOI：
10.1007/s11064-019-02846-w
复制
发表时间：
2019-09-01
影响因子：
4.4
通讯作者：
Kim, Hyung Jun
中科院分区：
文献类型：
--
作者：
Nam, Jung Woo;Lee, Mi Jee;Kim, Hyung Jun
本研究的目的是评价F-18-FDG PET/MRI在两种不同的周围神经病理性疼痛模型中的诊断效果。将12只左侧坐骨神经手术大鼠随机分为假手术组（对照组）、挤压伤组和慢性压迫伤组（实验组）。术后3周采用缩足阈值（RevWT）、PET/MRI图像最大标准摄取值（SUVR）和神经损伤近端和远端有髓轴突计数（MAxR）等方法评估神经损伤。结果进行量化和统计分析。与对照组相比，挤压伤在RevWT（p < 0.0001）和SUVR（p = 0.027）方面表现出显著差异，CCI组在RevWT（p < 0.0001）、SUVR（p = 0.001）和MAxR（p = 0.048）方面表现出显著差异。两个实验组之间的所有评估均无显著差异。相关性分析表明，RevWT和SUVR评估高度相关（r = -0. 710，p = 0. 010），SUVR和MAxR高度相关（r = 0. 611，p = 0. 035）。然而，RevWT和MAxR之间没有显著相关性。PET扫描可能是一种有价值的成像方式，使非侵入性，客观诊断周围神经损伤引起的神经性疼痛。此外，MRI与PET融合可能有助于澄清软组织结构的解剖位置，包括周围神经。
The aim of this study was to evaluate the diagnostic efficacy of F-18-FDG PET/MRI in two different peripheral neuropathic pain models using the injured rat sciatic nerves. Twelve rats, with operation on left sciatic nerves, were evenly divided into three groups: sham surgery (control group), crushing injury and chronic constriction injury (CCI) (experimental groups). The nerve damage was assessed at 3 weeks postoperatively using following methods: paw withdrawal threshold values (RevWT), maximum standardized uptake values on PET/MRI images (SUVR), and counting the number of myelinated axons in proximal and distal sites of nerve injury (MAxR). The results were quantified and statistically analyzed. Compared to the control group, the crushing injury demonstrated significant differences in RevWT (p < 0.0001) and SUVR (p = 0.027) and the CCI group demonstrated significant differences in RevWT (p < 0.0001), SUVR (p = 0.001) and MAxR (p = 0.048). There were no significant differences between the two experimental groups for all assessments. Correlation analysis demonstrated that RevWT and SUVR assessments were highly correlated (r = -- 0.710, p = 0.010), and SUVR and MAxR were highly correlated (r = 0.611, p = 0.035). However, there was no significant correlation between RevWT and MAxR. The PET scan may be a valuable imaging modality to enable noninvasive, objective diagnosis of neuropathic pain caused by peripheral nerve injury. Also, MRI fused with PET may help clarify the anatomic location of soft tissue structures, including the peripheral nerves.