Platelet-activating factor in infants at risk for necrotizing enterocolitis
Platelet-activating factor in infants at risk for necrotizing enterocolitis
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DOI：
10.1067/mpd.2001.110132
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发表时间：
2001-01-01
影响因子：
5.1
通讯作者：
Kornecki, E
中科院分区：
文献类型：
--
作者：
Rabinowitz, SS;Dzakpasu, P;Kornecki, E
背景资料：血小板活化因子（PAF）是一种异质性磷脂，已被牵连参与围产期疾病的过程，包括坏死性小肠结肠炎（NEC）。方法：基线血PAF和相关脂质（PAF-LL）的水平进行了测量，为164名婴儿在风险NEC从3个新生儿重症监护病房。结果：无NEC的11例患儿PAF-LL平均峰值为2.03 ± 1.96 ng/mL。II期（n = 6）和III期（n = 5）NEC婴儿的PAF-LL峰值升高（平均峰值13.6 +/- 6.9 ng/mL）。无PAF-LT，在NEC II期或III期期间从婴儿中获得的测量值
Background: Platelet-activating factor (PAF) is a heterogeneous phospholipid that has been implicated as participating in a number of perinatal disease processes including necrotizing enterocolitis (NEC).Methods: Baseline blood levels of PAF and related lipids (PAF-LL) were measured for 164 infants at risk for NEC from 3 neonatal intensive care units. Serial levels were obtained from the 11 infants in whom NEC developed.Results: The mean peak PAF-LL in the infants without NEC was 2.03 +/- 1.96 ng/mL. Infants with stage II (n = 6) and III (n = 5) NEC had elevated peak PAF-LL values (mean peak value 13.6 +/- 6.9 ng/mL). No PAF-LT, measurements obtained from infants during stage II or III NEC were