Response of rat model of Pneumocystis carinii pneumonia to continuous infusion of deferoxamine.
Response of rat model of Pneumocystis carinii pneumonia to continuous infusion of deferoxamine.
复制标题
卡氏肺孢子虫肺炎大鼠模型对持续输注去铁胺的反应。
DOI：
10.1128/aac.39.7.1442
复制
发表时间：
1995
影响因子：
4.9
通讯作者：
ClarksonJr,AB
中科院分区：
文献类型：
--
作者：
Merali,S;Chin,K;Grady,RW;Weissberger,L;ClarksonJr,AB
The iron-chelating drug deferoxamine mesylate (DFO) is active against Pneumocystis carinii in vitro and in rat and mouse models of P. carinii pneumonia. Because DFO has a short half-life, daily divided or continuous dosage was expected to improve the dose response, as is the case with DFO treatment of malaria. Therefore, results of single daily intraperitoneal injections were compared with results of an evenly divided four-times-daily dosage and the efficacy of delivery with implanted infusion pumps. The highest bolus dosage (1,000 mg kg-1 of body weight day-1) was as effective as the standard combination of trimethoprim with sulfamethoxazole. Unexpectedly, very little improvement was observed with the divided or continuous dosage, and several mechanisms that could account for this are discussed.
