Clinical features and prognostic factors of patients with metastatic renal cell carcinoma stratified by age.
Clinical features and prognostic factors of patients with metastatic renal cell carcinoma stratified by age.
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DOI：
10.18632/aging.202637
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发表时间：
2021-03-03
期刊：
影响因子：
--
通讯作者：
Lei Y
中科院分区：
文献类型：
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作者：
Yue G;Deyu L;Lianyuan T;Fengmin S;Mei G;Yajun H;Wenwen Z;Lei Y
本研究比较了转移性肾细胞癌（mRCC）患者按年龄分层的临床病理特征和生存期，以确定临床特征和预后因素。从监测、流行病学和最终结果数据库中确定2010年至2015年间肾细胞癌（RCC）患者。年龄是RCC、mRCC、mRCC透明细胞肾细胞癌及肺相关转移患者的独立预后因素。年轻组和老年组之间存在许多显著差异，包括婚姻状况、种族、性别、诊断年份、组织学分级、侧边性、T分期、N分期、肿瘤大小、治疗类型（包括手术、放疗或化疗）以及肝、肺或脑的有机转移类型（P<0.05）。此外，老年组与年轻组相比，自然转移方式不同，总生存率较低（P<0.05）。婚姻状况、性别、诊断年份、组织学分级、N分期、手术、化疗、肺转移、肝转移是老年患者预后的独立影响因素（P<0.05）。年龄在mRCC中起着显著的作用，老年mRCC患者是一个特殊的个体群体，其临床特征和预后因素与年轻患者不同；因此，这些患者需要特别注意。
This study compared the clinicopathological characteristics and survival of patients with metastatic renal cell carcinoma (mRCC) stratified by age to identify clinical features and prognostic factors. Patients with renal cell carcinoma (RCC) between 2010 and 2015 were identified from the Surveillance, Epidemiology and End Results database. Age was an independent prognostic factor for patients with RCC, mRCC, mRCC of clear cell renal cell carcinoma and lung-related metastases. There were many significant differences between the younger and older groups, including differences in marital status, race, sex, year of diagnosis, histology grade, laterality, T stage, N stage, tumor size, type of treatment, including surgery, radiation or chemotherapy, and pattern of organic metastasis to the liver, lung, or brain (P<0.05). Moreover, different natural metastasis patterns and poorer overall survival were observed in the older group compared with the younger group (P<0.05). Parameters, including marital status, sex, year of diagnosis, histological grade, N stage, surgery, chemotherapy, lung metastasis and liver metastasis, were independent prognostic factors for elderly patients (P<0.05). Age plays a significant role in mRCC, and elderly patients with mRCC are a special group of individuals whose clinical characteristics and prognostic factors are different from those of younger patients; therefore, these patients require special attention.