Environmental tobacco smoke and breast cancer incidence
Environmental tobacco smoke and breast cancer incidence
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DOI：
10.1016/j.envres.2003.08.009
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发表时间：
2004-10-01
影响因子：
8.3
通讯作者：
Santella, RM
中科院分区：
文献类型：
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作者：
Gammon, MD;Eng, SM;Santella, RM
为了评估环境烟草烟雾（ETS）是否影响乳腺癌的发病率，对一项基于人群的病例对照研究的数据进行了分析。通过面对面问卷调查评估的可用ETS信息的受访者包括1356例新诊断病例和1383例对照。相对于在整个生命过程中没有报告居住ETS暴露的非吸烟者，乳腺癌的比值比（OR）与ETS暴露、主动吸烟或主动吸烟和被动吸烟的联合测量（OR，1.15，95%CI，0.90，1.48）没有显著升高。然而，在与吸烟配偶生活超过27年的非吸烟者中，OR增加（2.10，95% CI，1.47，3.02），尽管没有明显的剂量反应。此外，仅在ER受体阳性肿瘤的女性中，主动吸烟和被动吸烟的OR均增加（ER+PR+为1.42，95% CI，1.00，2.00）。我们的数据表明，如果ETS对乳腺癌有影响，这种影响仅限于选定的女性亚组，例如长期暴露于吸烟配偶的女性。(C)2003年爱思唯尔公司All rights reserved.
To evaluate whether environmental tobacco smoke (ETS) influences breast cancer incidence, data from a population-based case-control study were analyzed. Respondents with available ETS information assessed by in-person questionnaires included 1356 newly diagnosed cases and 1383 controls. Relative to nonsmokers who reported no residential ETS exposure throughout the life course, the odds ratios (OR) for breast cancer were not substantially elevated in relation to ETS exposure, active smoking, or a joint measure of active and passive smoking (OR, 1.15, 95% CI, 0.90, 1.48). An increased OR, however, was noted among nonsmokers who lived with a smoking spouse for over 27 years (2.10, 95% CI, 1.47, 3.02), although no dose-response was evident. Also, among women with hormone-receptor-positive tumors only, the OR for both active and passive smoking was increased (1.42 for ER+PR+, 95% CI, 1.00, 2.00). Our data suggest that if there is an effect for ETS on breast cancer, that effect is restricted to selected subgroups of women, such as those with long-term exposure from a smoking spouse. (C) 2003 Elsevier Inc. All rights reserved.