Monocyte chemoattractant protein-1 and recurrent cardiovascular events in patients with stable coronary heart disease
Monocyte chemoattractant protein-1 and recurrent cardiovascular events in patients with stable coronary heart disease
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DOI：
10.1002/clc.4960280109
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发表时间：
2005-01-01
影响因子：
2.7
通讯作者：
Behar, S
中科院分区：
文献类型：
--
作者：
Haim, M;Tanne, D;Behar, S
背景资料：单核细胞趋化蛋白-1（MCP-1）参与单核细胞向血管壁的募集。假设：本研究的目的是评估血清MCP-1浓度与慢性冠心病患者未来心血管事件风险之间的潜在相关性。基线血清样本取自参加二级预防研究的冠心病患者。MCP-1水平测定在随访期间复发的心血管事件的患者（n = 233），并与年龄和性别相匹配的controls.Results水平进行比较：有没有在病例和对照组之间的血清MCP-1水平的差异。MCP-1血清浓度（160 pg/ml）的每1个标准差的心血管事件复发的相对几率为1.19（95%置信区间，0.95-1.45）。观察到MCP-1浓度增加三分位数时，复发性心血管事件的相对几率没有增加。结论：MCP-1水平升高与稳定性冠心病患者心血管事件的长期风险无关。
Background: Monocyte chemoattractant protein-1 (MCP-1) participates in the recruitment of mononuclear cells to the vessel wall.Hypothesis: The aim of the study was to evaluate the potential association between serum concentration of MCP-1 and risk of future cardiovascular events in patients with chronic coronary heart disease.Methods: A nested case control design was used. Baseline serum samples were taken from patients with coronary heart disease who were enrolled in a secondary prevention study. The MCP-1 levels were measured in those patients who had recurrent cardiovascular events during follow-up (n = 233) and compared with levels in age- and gender-matched controls.Results: There were no differences in serum MCP-1 levels between cases and controls. The relative odds of a recurrent cardiovascular event for each I standard deviation difference in MCP-1 serum concentration (160 pg/ml) was 1.19 (95% confidence interval, 0.95-1.45). No increase in the relative odds for recurrent cardiovascular events was observed per increasing tertiles of MCP-1 concentrations.Conclusion: Elevated MCP-1 levels are not associated with long-term risk of cardiovascular events in patients with stable coronary disease.