Altered immunity in hemophilia correlates with the presence of antibody to human T-cell lymphotropic virus type III (HTLV-III).
Altered immunity in hemophilia correlates with the presence of antibody to human T-cell lymphotropic virus type III (HTLV-III).
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血友病中免疫力的改变与人类 T 细胞嗜淋巴细胞病毒 III 型 (HTLV-III) 抗体的存在相关。
DOI：
10.1007/bf00915362
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发表时间：
1986
影响因子：
9.1
通讯作者：
Kirkpatrick,CH
中科院分区：
文献类型：
--
作者：
HorsburghJr,CR;Davis,KC;Hasiba,U;Weiss,SH;Goedert,JJ;Sarin,P;Kirkpatrick,CH
对29例异性恋血友病患者进行病史调查、体格检查、实验室免疫功能评估、延迟性超敏皮肤试验和人t细胞嗜淋巴病毒III型（HTLV-III）抗体测定。HTLV-III抗体阳性16例，阴性13例。无获得性免疫缺陷综合征（AIDS）患者。有HTLV-III抗体的患者在前5年内接受的因子浓缩物的单位和数量明显高于无抗体的患者。HTLV-III抗体阳性患者的总T细胞（Leu-1阳性）和辅助T细胞（Leu-3阳性）明显少于HTLV-III阴性患者。抗体阳性的患者也有增加的IgG量和减少胸腺嘧啶掺入响应于体外的刀豆蛋白。白细胞对植物血凝素（PHA）、美洲商陆丝裂原、念珠菌、破伤风或纯化蛋白衍生物（PPD）的反应没有差异，γ干扰素或白细胞介素-2 （IL-2）的产生没有明显的损伤，也没有能量。10例HTLV-III抗体患者在最初评估1年后再次进行免疫学研究。抑制性（leu -2阳性）T细胞显著增加，但总T细胞或辅助T细胞数量、辅助/抑制比值或T细胞功能测定均无显著增加。我们得出结论，血友病患者的免疫异常是与HTLV-III接触的结果，但这些异常可能在较长时间内保持稳定。
Twenty-nine heterosexual patients with hemophilia were investigated with histories, physical examinations, laboratory evaluations of immune function, delayed hypersensitivity skin tests, and assays for antibody to human T-cell lymphotropic virus type III (HTLV-III). Sixteen patients were HTLV-III antibody positive and 13 were HTLV-III antibody negative. No patient had the acquired immune deficiency syndrome (AIDS). Patients who had antibody to HTLV-III had received significantly more units and lots of factor concentrates in the preceding 5 years than those who did not have antibody. HTLV-III antibody-positive patients had significantly fewer total T cells (Leu-1 positive) and significantly fewer helper T cells (Leu-3 positive) than HTLV-III negative patients. Antibody-positive patients also had increased amounts of IgG and decreased thymidine incorporation in response to concanavalin Ain vitro. There were no differences inin vitrolymphocyte responses to phytohemagglutinin (PHA), pokeweed mitogen,Candida, tetanus, or purified protein derivative (PPD), no significant impairments of gamma interferon or interleukin-2 (IL-2) production, and no anergy. Ten patients with antibody to HTLV-III had immunologic studies repeated 1 year after the original evaluation. A significant increase was seen in suppressor (Leu-2-positive) T cells but not in total T-cell or helper T-cell numbers, helper/suppressor ratios, or T-cell functional assays. We conclude that the immune abnormalities in hemophiliacs are the result of contact with HTLV-III but that these abnormalities may remain stable over prolonged periods.