Executive dysfunction and presbycusis in older persons with and without memory loss and dementia.
Executive dysfunction and presbycusis in older persons with and without memory loss and dementia.
复制标题
DOI：
10.1097/wnn.0b013e3181d748d7
复制
发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Larson EB
中科院分区：
文献类型：
--
作者：
Gates GA;Gibbons LE;McCurry SM;Crane PK;Feeney MP;Larson EB
确定与年龄相关的听觉处理功能障碍与执行功能的关系。中枢性听觉功能障碍在阿尔茨海默氏症中很常见，但其机制尚未确定。参与者：来自成人思想变化监测队列的313名志愿者，具有足够的外周听力。结果测量：（1）外周听力;（2）听觉诱发电位;（3）中枢听觉测试（同侧竞争信息合成句子识别，双耳分音句子识别，双耳分音数字）;（4）执行功能：线索制作;时钟绘制，Stroop颜色和单词，以及认知能力筛查仪器测量精神集中度的子测试。一个复合执行功能得分使用项目反应理论。综合执行功能评分与每项中央听觉指标显着相关，解释了8-21%的方差。轨迹B与听觉结果的相关性最强，解释了8-14%的方差。当被诊断为记忆障碍或痴呆的参与者被排除在外时，执行功能和中枢听觉功能之间的关系仍然显着。在老年人中，执行功能下降与中枢听觉处理有关，但与初级听觉功能无关。这表明中枢性老年性耳聋和执行功能障碍可能是由类似的神经退行性过程引起的。
Determine the relation of age-related auditory processing dysfunction and executive functioning. Central auditory dysfunction is common in Alzheimer’s dementia but the mechanism is not established. Participants: 313 volunteers from the Adult Changes in Thought surveillance cohort with adequate peripheral hearing. Outcome measures (1) peripheral audition; (2) auditory-evoked potentials; (3) central auditory tests (Synthetic Sentence Identification with Ipsilateral Competing Message, Dichotic Sentence Identification, Dichotic Digits; (4) Executive Functioning: Trail Making; Clock Drawing, Stroop Color and Word, and subtests from the Cognitive Abilities Screening Instrument measuring mental concentration. A composite executive functioning score was created using item response theory. The composite executive functioning score was significantly associated with each central auditory measure, explaining 8–21% of the variance. Trails B was most strongly associated with the auditory outcomes, explaining 8–14% of the variance. The relation between executive functioning and central auditory function was still significant when participants diagnosed with memory impairment or dementia were excluded. In elderly persons, reduced executive functioning is associated with central auditory processing, but not with primary auditory function. This suggests that central presbycusis and executive dysfunction may result from similar neurodegenerative processes.