Differential effect of anterior cingulate cortex lesion on mechanical hypersensitivity and escape/avoidance behavior in an animal model of neuropathic pain
Differential effect of anterior cingulate cortex lesion on mechanical hypersensitivity and escape/avoidance behavior in an animal model of neuropathic pain
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DOI：
10.1016/j.expneurol.2004.04.003
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发表时间：
2004-07-01
影响因子：
5.3
通讯作者：
Fuchs, PN
中科院分区：
文献类型：
--
作者：
LaGraize, SC;Labuda, CJ;Fuchs, PN
各种边缘系统的结构已经牵连在处理有害信息。一个这样的结构是前扣带皮层（ACC），该区域被认为调节与疼痛的情感/动机成分相关的有害输入的高阶处理。本实验通过在L5脊神经结扎神经病理性疼痛模型中在ACC电解损伤之前和之后测量缩爪阈值和逃避/回避反应来检查ACC在高级疼痛处理中的参与。在位置/逃避回避范例中，当动物处于室的优选黑暗区域时，机械刺激患病的爪，动物在灯光区。逃逸/回避定义为从首选的黑暗区域转移到在室的明亮区域中花费的时间增加。L5结扎的动物显著降低机械缩爪阈值（超敏反应）并增强逃避/回避行为。L5结扎动物的ACC损伤没有改变机械过敏，但明显减少逃避/回避行为。焦虑，作为衡量使用光增强惊吓范例，没有改变ACC病变。这些结果突出了新的行为测试范例的效用，并提供了额外的支持的作用，ACC在高阶处理有害信息，这表明ACC病变选择性地减少与神经病变引起的超敏反应的负面影响。(C)2004爱思唯尔公司All rights reserved.
Various limbic system structures have been implicated in processing noxious information. One such structure is the anterior cingulate cortex (ACC), a region that is thought to modulate higher order processing of noxious input related to the affective/motivational component of pain. The present experiment examined the involvement of the ACC in higher order pain processing by measuring paw withdrawal threshold and escape/avoidance responses in the L5 spinal nerve ligation model of neuropathic pain before and following electrolytic lesion of the ACC. In the place/escape avoidance paradigm, the afflicted paw is mechanically stimulated when the animal is in the preferred dark area of the chamber and the contralateral paw is stimulated when the animal is in the light area. Escape/avoidance was defined as a shift from the preferred dark area to an increase of time spent in the light area of the chamber. Animals with L5 ligation bad significantly lower mechanical paw withdrawal threshold (hypersensitivity) and enhanced escape/avoidance behavior. ACC lesion in animals with L5 ligation did not alter mechanical hypersensitivity, but did significantly decrease escape/avoidance behavior. Anxiety, as measured using the light-enhanced startle paradigm, was not altered by ACC lesion. These results highlight the utility of novel behavioral test paradigms and provide additional support for the role of the ACC in higher order processing of noxious information, suggesting that ACC lesions selectively decrease negative affect associated with neuropathy-induced hypersensitivity. (C) 2004 Elsevier Inc. All rights reserved.