Metal-polyphenol nanodots loaded hollow MnO2 nanoparticles with a ?dynamic protection? property for enhanced cancer chemodynamic therapy
Metal-polyphenol nanodots loaded hollow MnO2 nanoparticles with a ?dynamic protection? property for enhanced cancer chemodynamic therapy
复制标题
负载金属多酚纳米点的空心 MnO2 纳米颗粒具有“动态保护”特性，可增强癌症化学动力学治疗
DOI：
10.1016/j.jcis.2022.12.088
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发表时间：
2022-12-22
影响因子：
9.9
通讯作者：
Li, Cao
中科院分区：
文献类型：
--
作者：
Duan, Junlin;Liao, Tao;Li, Cao
Chemodynamic therapy (CDT) is a novel cancer therapeutic strategy. However, barriers such as high glutathione (GSH) concentration and low concentration of metal ions intracellular reduce its treatment effect. In this work, a nanosystem named GA-Fe@HMDN-PEI-PEG with a "dynamic protection" property was reported for enhanced cancer CDT. Mesoporous hollow manganese dioxide (MnO2) nanoparticle (HMDN) was prepared to load gallic acid-ferrous (GA-Fe) nanodots fabricated from gallic acid (GA) and ferrous ion (Fe2+). Then the pores of HMDN were blocked by polyethyleneimine (PEI), which was then grafted with methoxy poly(ethylene glycol) (mPEG) through a pH-sensitive benzoic imine bond. mPEG could protect the nanoparticles (NPs) against the nonspecific uptake by normal cells and enhance their accumulation in the tumor. However, in the slightly acidic tumor microenvironment, hydrolysis of benzoic imine led to DePEGylation to reveal PEI for enhanced uptake by cancer cells. The reaction between HMDN and GSH could consume GSH and obtain manganese ion (Mn2+) for the Fenton-like reaction for
