The dynamics of the cellular immune response to HIV infection: implications for vaccination
The dynamics of the cellular immune response to HIV infection: implications for vaccination
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DOI：
10.1098/rstb.2000.0637
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发表时间：
2000-08-29
影响因子：
6.3
通讯作者：
Rowland-Jones, S
中科院分区：
文献类型：
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作者：
McMichael, AJ;Callan, M;Rowland-Jones, S
最近在测量T细胞对病毒的反应方面取得的进展使人们对这些T细胞如何反应有了新的认识。在急性感染中，有大量的CD8（+）T细胞对EB病毒（EBV）和人类免疫缺陷病毒（HIV）的反应。这些T细胞中的许多是效应细胞，只有少数似乎能够维持免疫记忆。在持续性病毒感染中，高水平的抗原特异性效应细胞持续存在。如果病毒不持续存在，效应器的数量会减少，但记忆会保持，并对新的挑战做出快速反应。一种只刺激T细胞反应的疫苗可能会在这些记忆细胞反应足够快，从而在感染病毒建立之前产生大量效应子时起到保护作用。
Recent advances in measuring T-cell responses to viruses have led to new insights into how these T cells respond. In the acute infection there are massive CD8(+) T-cell responses to both Epstein-Barr virus (EBV) and to human immunodeficiency virus (HIV). Many of these T cells are effector cells and only a minority appear to be capable of maintaining immunological memory. In persistent virus infections, high levels of antigen-specific effector cells persist. If virus does not persist, the effecters fade in number but memory is maintained and is primed to react rapidly to a new challenge. A vaccine that stimulates only T-cell responses may protect when these memory cells respond rapidly enough to generate high numbers of effectors before the infecting virus becomes established.