Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies.
Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies.
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DOI：
10.1136/gut.2011.237727
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发表时间：
2011-12
期刊：
影响因子：
24.5
通讯作者：
Le Marchand L
中科院分区：
文献类型：
--
作者：
Cheng I;Caberto CP;Lum-Jones A;Seifried A;Wilkens LR;Schumacher FR;Monroe KR;Lim U;Tiirikainen M;Kolonel LN;Henderson BE;Stram DO;Haiman CA;Le Marchand L
Diabetes has been positively associated with the risk of colorectal cancer. We investigated whether recently established risk variants for diabetes also have effects on colorectal cancer. Nineteen SNPs associated with type-2 diabetes (T2D) in genome-wide association studies were tested in a case-control study of 2,011 colorectal cancer cases and 6,049 controls nested in the Multiethnic Cohort as part of the Population Architecture using Genomics and Epidemiology (PAGE) initiative. Odds ratios (OR) and 95% Confidence Intervals (CI) were estimated by unconditional logistic regression to evaluate the association between SNPs and colorectal cancer risk, adjusting for age, sex, and race/ethnicity. Permutation testing was conducted to correct for multiple hypothesis testing. Four type 2 diabetes SNPs were associated with colorectal cancer risk: rs7578597 (THADA), rs864745 (JAZF1), rs5219 (KCNJ11), and rs7961581 (TSPAN8, LGR5). The strongest association was for the rs7578597 (THADA) Thr1187Ala missense polymorphism (Ptrend = 0.004 adjusted for multiple testing) with the high risk allele for colorectal cancer being the low risk allele for diabetes. Similar patterns of associations were seen with further adjustment for diabetes status and body mass index. The association of diabetes status with colorectal cancer risk was somewhat weakened after adjustment for these SNPs. Our findings suggest that diabetes risk variants also influence colorectal cancer susceptibility, possibly through different mechanisms than for diabetes.
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.9
作者：
Kosoy, Roman;Nassir, Rami;Tian, Chao;White, Phoebe A.;Butler, Lesley M.;Silva, Gabriel;Kittles, Rick;Alarcon-Riquelme, Marta E.;Gregersen, Peter K.;Belmont, John W.;De La Vega, Francisco M.;Seldin, Michael F.
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影响因子：
11.2
作者：
Greco, Celine;Bralet, Marie-Pierre;Boucheix, Claude
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Boucheix, Claude
DOI：
10.1073/pnas.101132598
发表时间：
2001-05-22
影响因子：
11.1
作者：
Koontz, JI;Soreng, AL;Sklar, J
通讯作者：
Sklar, J