An a2-adrenergic receptor is involved in larval metamorphosis in the mussel, Mytilus coruscus
An a2-adrenergic receptor is involved in larval metamorphosis in the mussel, Mytilus coruscus
复制标题
É2-肾上腺素能受体参与贻贝 (Mytilus coruscus) 幼虫的变态
DOI：
10.1080/08927014.2019.1685661
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发表时间：
2019-11-12
期刊：
影响因子：
2.7
通讯作者：
Yang, Jin-Long
中科院分区：
文献类型：
--
作者：
Liang, Xiao;Chen, Ke;Yang, Jin-Long
摘要变态是海洋无脊椎动物从幼体到幼鱼的生命周期转换过程中的关键环节。虽然肾上腺素能受体（AR）的激动剂和拮抗剂的数量是已知的调控幼虫变态厚壳贻贝（Mc），在这个物种的AR基因的调制幼虫变态的分子基础仍然是难以捉摸的。在此，AR基因在M.利用RNA干扰技术研究了厚吻鲈幼虫变态过程。Mcα2AR转录本在幼虫发育的全过程中均有表达，且在后幼虫中的表达水平显著高于原面盘幼虫。Mcα 2AR基因敲低导致Mcα2AR转录本的丰度显著降低，并显著抑制了M.厚壳幼虫这些发现为研究黑腹果蝇幼虫变态调控的分子基础提供了新的思路。由AR基因控制。
Abstract Metamorphosis is crucial in the life-cycle transition between the larval and juvenile stages of marine invertebrates. Although a number of agonists and antagonists of the adrenergic receptor (AR) are known to regulate larval metamorphosis in Mytilus coruscus (Mc), the molecular basis of the modulation of larval metamorphosis by the AR gene in this species remains elusive. Herein, the role of the AR gene in M. coruscus larval metamorphosis using the RNA interference technique was examined. The Mcα2AR transcript was observed to be present during the entire process of larval development and its level in the post-larvae was significantly increased compared to that in the pediveligers. Mcα2AR-knockdown resulted in a substantial reduction in the abundance of the Mcα2AR transcript and significantly inhibited the metamorphosis of M. coruscus larvae. These findings provide new insights into the molecular basis of modulation of larval metamorphosis in M. coruscus by the AR gene.