Atherosclerosis inflammation Imaging with 18F-FDG PET:: Carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations
Atherosclerosis inflammation Imaging with 18F-FDG PET:: Carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations
复制标题
DOI：
10.2967/jnumed.107.050294
复制
发表时间：
2008-06-01
影响因子：
9.3
通讯作者：
Fayad, Zahi A.
中科院分区：
文献类型：
--
作者：
Rudd, James H. F.;Myers, Kelly S.;Fayad, Zahi A.
使用F-18-FDG PET进行动脉粥样硬化成像对于追踪斑块内的炎症和监测对药物治疗的反应是有用的。该技术在外周动脉疾病中的短期可重复性尚未得到评估，F-18-FDG定量的最佳方法仍在争论中。我们使用F-18-FDG PET对20例血管疾病患者进行两次成像，间隔14天，并使用这些数据评估再现性措施，并比较两种F-18-FDG摄取测量方法。我们还回顾了有关定量方法的文献，以确定未来研究中动脉F-18-FDG摄取的最佳测量方法。方法：20例血管疾病患者在给予F-18-FDG 90 min后行髂、股、颈动脉PET/CT检查。19例患者在2周时进行重复检测。用CT进行共配准和衰减校正。血管F-18-FDG摄取测量为平均和最大血液标准化摄取值（SUV），即靶背景比（TBR）。我们评估了观察者之间、观察者之间和观察者内部的一致性。结果：19例患者完成了两次影像学检查。颈动脉和外周动脉对F-18-FDG信号均具有极好的短期再现性，所有再现性指标的类内相关系数均大于0.8。用于量化F-18-FDG摄取的平均和最大TER测量都具有同样的可重复性。颈动脉的F-18-FDG摄取明显高于髂血管和股血管（两者均P < 0.001）。结论：我们发现颈动脉、髂动脉和股动脉的平均和最大TBR具有高度可重复性。我们建议平均TBR用于跟踪全身动脉治疗，而最大TBR用于检测和监测局部斑块治疗是最佳的。
Atherosclerosis imaging with F-18-FDG PET is useful for tracking inflammation within plaque and monitoring the response to drug therapy. Short-term reproducibility of this technique in peripheral artery disease has not been assessed, and the optimal method of F-18-FDG quantification is still debated. We imaged 20 patients with vascular disease using F-18-FDG PET twice, 14 d apart, and used these data to assess reproducibility measures and compare 2 methods of F-18-FDG uptake measurement. We also reviewed the literature on quantification methods to determine the optimal measures of arterial F-18-FDG uptake for future studies. Methods: Twenty patients with vascular disease underwent PET/CT of the iliac, femoral, and carotid arteries 90 min after F-18-FDG administration. In 19 patients, repeat testing was performed at 2 wk. Coregistration and attenuation correction were performed with CT. Vessel F-18-FDG uptake was measured as both the mean and maximum blood-normalized standardized uptake value (SUV), known as the target-to-background ratio (TBR). We assessed interscan, interobserver, and intraobserver agreement. Results: Nineteen patients completed both imaging sessions. The carotid and peripheral arteries all have excellent short-term reproducibility of the F-18-FDG signal, with intraclass correlation coefficients all greater than 0.8 for all measures of reproducibility. Both mean and maximum TER measurements for quantifying F-18-FDG uptake are equally reproducible. F-18-FDG uptake was significantly higher in the carotid arteries than in both iliac and femoral vessels (P < 0.001 for both). Conclusion: We found that both mean and maximum TBR in the carotid, iliac, and femoral arteries were highly reproducible. We suggest the mean TBR be used for tracking systemic arterial therapies, whereas the maximum TBR is optimal for detecting and monitoring local, plaque-based therapy.