Subcellular neural probes from single-crystal gold nanowires.
Subcellular neural probes from single-crystal gold nanowires.
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DOI：
10.1021/nn5024522
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发表时间：
2014-08-26
期刊：
影响因子：
17.1
通讯作者：
Kim B
中科院分区：
文献类型：
--
作者：
Kang M;Jung S;Zhang H;Kang T;Kang H;Yoo Y;Hong JP;Ahn JP;Kwak J;Jeon D;Kotov NA;Kim B
减小神经电极的尺寸对于改善神经假体设备的功能、开发针对神经和神经退行性疾病的有效疗法以及长期的脑机接口至关重要。典型的神经电极是尺寸从几十微米到数百微米的微型制造设备。为了减少局部组织损伤和大脑的慢性免疫反应，它们的进一步微型化是必要的。在这里，我们报道了基于直径为∼100 nm的单晶金纳米线的亚细胞尺寸的神经电极。无缺陷金纳米粒子的独特机械和电学特性使其能够在活体小鼠大脑中植入和记录单个神经元活动，尽管与最接近的类似物相比，其尺寸缩小了∼50倍。电极尺寸的减小能够记录神经活动，并提高空间分辨率，并对小鼠的不同社交情况做出反应，区分大脑活动。癫痫发作中心的成功定位也是使用多电极探头作为NW电极诊断潜力的演示。这项研究证明了使用亚细胞大小的电极进行单个神经元记录的现实性，这可能被认为是用于慢性脑部疾病的各种研究的关键点。
Size reduction of neural electrodes is essential for improving the functionality of neuroprosthetic devices, developing potent therapies for neurological and neurodegenerative diseases, and long-term brain–computer interfaces. Typical neural electrodes are micromanufactured devices with dimensions ranging from tens to hundreds of micrometers. Their further miniaturization is necessary to reduce local tissue damage and chronic immunological reactions of the brain. Here we report the neural electrode with subcellular dimensions based on single-crystalline gold nanowires (NWs) with a diameter of ∼100 nm. Unique mechanical and electrical properties of defect-free gold NWs enabled their implantation and recording of single neuron-activities in a live mouse brain despite a ∼50× reduction of the size compared to the closest analogues. Reduction of electrode dimensions enabled recording of neural activity with improved spatial resolution and differentiation of brain activity in response to different social situations for mice. The successful localization of the epileptic seizure center was also achieved using a multielectrode probe as a demonstration of the diagnostics potential of NW electrodes. This study demonstrated the realism of single-neuron recording using subcellular-sized electrodes that may be considered a pivotal point for use in diverse studies of chronic brain diseases.