Imported zika virus infection from the cook islands into australia, 2014.
Imported zika virus infection from the cook islands into australia, 2014.
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DOI：
10.1371/currents.outbreaks.4635a54dbffba2156fb2fd76dc49f65e
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发表时间：
2014-06-02
期刊：
影响因子：
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通讯作者：
Gair, Richard
中科院分区：
文献类型：
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作者：
Pyke, Alyssa T;Daly, Michelle T;Gair, Richard
澳大利亚昆士兰州汤斯维尔的一名女性居民在最近前往库克群岛后被诊断出感染寨卡病毒。2014年3月采集的初始血清样本通过两种单独的寨卡病毒TaqMan实时RT-PCR和泛黄病毒RT-PCR检测呈阳性。完整库克群岛寨卡病毒包膜基因的核苷酸测序和基因组学显示，与亚洲血统中之前的柬埔寨2010序列有99.1%的同源性。此外，使用重组寨卡病毒血清学检测，在成对的急性期和恢复期血清之间检测到IgG和IgM抗体血清转换。这是已知的第一例输入性寨卡病毒感染病例，进入北方昆士兰州，那里存在潜在的蚊子媒介埃及伊蚊，也是澳大利亚境内确诊的第二例此类报告病例。
A female resident of Townsville, Queensland, Australia has been diagnosed with Zika virus infection following a recent trip to the Cook Islands. An initial serum sample collected in March, 2014 was positive by two separate Zika virus TaqMan real-time RT-PCRs and a pan-Flavivirus RT-PCR. Nucleotide sequencing and phylogenetics of the complete Cook Islands Zika virus envelope gene revealed 99.1% homology with a previous Cambodia 2010 sequence within the Asian lineage. In addition, IgG and IgM antibody seroconversions were detected between paired acute and convalescent phase sera using recombinant Zika virus serology assays. This is the first known imported case of Zika virus infection into northern Queensland where the potential mosquito vector Aedes aegypti is present and only the second such reported case diagnosed within Australia.