Uveal Melanoma and the IRIS® Registry (Intelligent Research in Sight): A Pilot Analysis and Future Directions.
Uveal Melanoma and the IRIS® Registry (Intelligent Research in Sight): A Pilot Analysis and Future Directions.
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葡萄膜黑色素瘤和 IRIS® 注册（智能研究展望）：试点分析和未来方向。
DOI：
10.1016/j.oret.2022.10.019
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Skalet,AlisonH
中科院分区：
文献类型：
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作者：
Uner,OgulE;Aronow,MaryE;Mruthyunjaya,Prithvi;Materin,MiguelA;Stacey,AndrewW;Wilson,Matthew;Afshar,Armin;Skalet,AlisonH
葡萄膜黑色素瘤（UM）虽然是成人中最常见的原发性眼内恶性肿瘤，但仍然是一种罕见的疾病，每年的发病率为每百万人约5至6人。IRIS®注册表（Intelligent Research in Sight）是全国最大的基于电子健康记录（EHR）的眼科注册表。它以自动化的方式收集信息，与许多其他临床数据库不同，这些数据库通常需要手动输入数据。鉴于IRIS Registry在评估罕见病方面的潜力，我们试图在IRIS Registry中识别和表征UM患者，以确定其作为研究UM工具的可行性。前面已经描述了IRIS Registry的方法。2查询时间为2019年9月6日。2013年至2017年间诊断的UM患者使用国际疾病分类第9版和第10版代码进行识别（表S1，可在www上获得）。ophthalmologyretina。org)。获得有关肿瘤、临床检查、治疗和视力结果的信息。患者得到合格诊断的日期被定义为索引日期。在UM诊断前（即前索引）和UM诊断后或最多1年（后索引）比较感兴趣的数据元素。
Uveal melanoma (UM), although the most common primary intraocular malignancy in adults, remains a rare condition with incidence of∼ 5 to 6 people per million per year. 1 The IRIS® Registry (Intelligent Research in Sight) is the nation’s largest electronic health record (EHR)-based ophthalmology registry. It collects information in an automated fashion, in contrast to many other clinical databases that typically require manual data entry. 2 Given the Registry’s potential in evaluating rare diseases, we sought to identify and characterize patients with UM within the IRIS Registry to determine its feasibility as a tool to study UM.The methods of the IRIS Registry have been previously described. 2 The query was performed on September 6, 2019. Patients with UM diagnosed between 2013 and 2017 were identified using the International Classification of Disease 9 and 10 edition codes (Table S1, available at www. ophthalmologyretina. org). Information regarding tumors, clinical examination, treatments, and visual outcomes were obtained. The date at which a patient was given a qualifying diagnosis was defined as the index date. Data elements of interest were compared before UM diagnosis (ie, preindex) and at or up to 1 year after UM diagnosis (postindex).