Metabolic Reprogramming of Stem Cell Epigenetics.
Metabolic Reprogramming of Stem Cell Epigenetics.
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DOI：
10.1016/j.stem.2015.11.012
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发表时间：
2015-12-03
期刊：
影响因子：
23.9
通讯作者：
Sartorelli V
中科院分区：
文献类型：
--
作者：
Ryall JG;Cliff T;Dalton S;Sartorelli V
多年来，干细胞代谢被视为细胞命运状态的副产品，而不是一个积极的调节机制，然而，现在越来越多的认识到，代谢途径影响与谱系承诺，规范和自我更新相关的表观遗传变化。在这里，我们审查如何代谢产物在糖酵解和氧化过程中产生的酶促反应，导致表观遗传修饰和转录调控。我们讨论了“代谢重编程”如何在幼稚和启动多能状态、体细胞重编程、造血和骨骼肌组织干细胞的背景下促进全球表观遗传变化，以及对再生医学的影响。
For many years, stem cell metabolism was viewed as a by product of cell fate status rather than an active regulatory mechanism, however there is now a growing appreciation that metabolic pathways influence epigenetic changes associated with lineage commitment, specification, and self-renewal. Here we review how metabolites generated during glycolytic and oxidative processes are utilized in enzymatic reactions leading to epigenetic modifications and transcriptional regulation. We discuss how “metabolic reprogramming” contributes to global epigenetic changes in the context of naïve and primed pluripotent states, somatic reprogramming, and hematopoietic and skeletal muscle tissue stem cells, and the implications for regenerative medicine.