A Map of Local Adaptation in Arabidopsis thaliana
A Map of Local Adaptation in Arabidopsis thaliana
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DOI：
10.1126/science.1209271
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发表时间：
2011-10-07
期刊：
影响因子：
56.9
通讯作者：
Wilczek, A. M.
中科院分区：
文献类型：
--
作者：
Fournier-Level, A.;Korte, A.;Wilczek, A. M.
当地的适应对于物种在快速的环境变化中的生存至关重要，但其遗传基础尚未得到很好的理解。生长模式植物拟南芥在四个地点在该物种的原生范围的田间实验中，我们确定了候选基因座的地方适应从全基因组的关联研究，在地理上不同的加入寿命健身。健身相关的基因座表现出当地适应的地理和气候特征。相对于基因组对照，高适应性等位基因通常分布在更靠近它们增加适应性的地点，占据特定和独特的气候空间。具有不同分子功能的独立位点对每个位点的适合度变异贡献最大。通过不同的遗传机制进行的独立的局部适应可能有助于在物种范围内对变化的环境做出灵活的进化反应。
Local adaptation is critical for species persistence in the face of rapid environmental change, but its genetic basis is not well understood. Growing the model plant Arabidopsis thaliana in field experiments in four sites across the species' native range, we identified candidate loci for local adaptation from a genome-wide association study of lifetime fitness in geographically diverse accessions. Fitness-associated loci exhibited both geographic and climatic signatures of local adaptation. Relative to genomic controls, high-fitness alleles were generally distributed closer to the site where they increased fitness, occupying specific and distinct climate spaces. Independent loci with different molecular functions contributed most strongly to fitness variation in each site. Independent local adaptation by distinct genetic mechanisms may facilitate a flexible evolutionary response to changing environment across a species range.