Animal models for simulating weightlessness
Animal models for simulating weightlessness
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发表时间：
1982
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通讯作者：
E. Morey-Holton;T. Wronski
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作者：
E. Morey-Holton;T. Wronski
美国宇航局开发了一种老鼠模型，用于在地球上模拟太空中经历的失重变化的某些方面，即卸载和流体转移。对太空飞行和大鼠头朝下悬挂模型收集的数据进行比较表明，该模型系统再现了太空飞行引起的许多生理变化。对于相同的参数，不同版本的大鼠模型的数据实际上是相同的；因此，只要维持模型的关键组成部分，即液体的头侧转移和/或后肢的卸载，对急性、慢性或代谢研究模型的修改就不会改变结果。
NASA has developed a rat model to simulate on earth some aspects of the weightlessness alterations experienced in space, i.e., unloading and fluid shifts. Comparison of data collected from space flight and from the head-down rat suspension model suggests that this model system reproduces many of the physiological alterations induced by space flight. Data from various versions of the rat model are virtually identical for the same parameters; thus, modifications of the model for acute, chronic, or metabolic studies do not alter the results as long as the critical components of the model are maintained, i.e., a cephalad shift of fluids and/or unloading of the rear limbs.