Trends in life expectancy of HIV-positive adults on antiretroviral therapy across the globe: comparisons with general population.
Trends in life expectancy of HIV-positive adults on antiretroviral therapy across the globe: comparisons with general population.
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DOI：
10.1097/coh.0000000000000298
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发表时间：
2016-09
影响因子：
4.1
通讯作者：
Egger M
中科院分区：
文献类型：
--
作者：
Wandeler G;Johnson LF;Egger M
抗逆转录病毒联合疗法（ART）的病毒学和免疫学结果的改善以及毒性的降低提高了艾滋病毒阳性患者接受ART治疗的预期寿命接近一般人群的希望。我们系统地回顾了文献，并总结了发表的艾滋病毒阳性人群接受抗逆转录病毒治疗的预期寿命估计。我们按时间和性别将他们的预期寿命与一般人的预期寿命或撒哈拉以南非洲艾滋病毒阴性人群的预期寿命进行比较。2006 - 2015年共发表相关研究10篇。三项研究来自加拿大，两项来自欧洲国家，三项来自撒哈拉以南非洲，两项是多国研究。所有研究和地区的预期寿命都随着时间的推移而增加。以艾滋病毒阴性或一般人群的预期寿命百分比表示，接受抗逆转录病毒治疗的艾滋病毒阳性人群20岁时的预期寿命估计范围从卢旺达（2008-2011年）的60.3% （95% CI 58.0-62.6）到加拿大（2008-2012年）的89.1% （95% CI 84.7-93.6）。除加拿大情况相反外，所有国家中艾滋病毒阴性或一般人口中艾滋病毒阳性妇女的预期寿命百分比高于艾滋病毒阳性男子。近年来，全世界接受抗逆转录病毒治疗的艾滋病毒阳性人群的预期寿命有所改善，但与一般人群和艾滋病毒阴性人群以及区域和性别之间仍然存在重大差距。
Improved virological and immunological outcomes and reduced toxicity of antiretroviral combination therapy (ART) raise the hope that life expectancy of HIV-positive persons on ART will approach that of the general population. We systematically review the literature and summarize published estimates of life expectancy of HIV-positive populations on ART. We compare their life expectancy with the life expectancy of the general or, in sub-Saharan Africa, HIV-negative populations, by time period and gender. Ten relevant studies were published from 2006 to 2015. Three studies were from Canada, two from European countries, three from sub-Saharan Africa and two were multi-country studies. Life expectancy increased over time in all studies and regions. Expressed as the percentage of life expectancy in the HIV-negative or general population, estimated life expectancy at age 20 years in HIV-positive people on ART ranged from 60.3% (95% CI 58.0–62.6) in Rwanda (2008–2011) to 89.1% (95% CI 84.7–93.6) in Canada (2008–2012). The percentage of the life expectancy in the HIV-negative or general population achieved was higher in HIV-positive women than in HIV-positive men in all countries, except for Canada where the opposite was the case. Life expectancy in HIV-positive people on ART has improved worldwide in recent years, but important gaps remain compared to the general and HIV-negative population, and between regions and genders.