No associations of Toll-like receptor 2 (TLR2)-196 to-174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese
No associations of Toll-like receptor 2 (TLR2)-196 to-174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese
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DOI：
10.1007/s10120-010-0567-y
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发表时间：
2010-11-01
期刊：
影响因子：
7.4
通讯作者：
Hamajima, Nobuyuki
中科院分区：
文献类型：
--
作者：
Hishida, Asahi;Matsuo, Keitaro;Hamajima, Nobuyuki
最近，在日本人群中报道了胃癌风险与toll样受体2 (TLR2) -196 ~ -174del功能多态性之间的关联。本研究旨在证实该多态性与胃癌风险、幽门螺杆菌血清阳性和胃萎缩风险的相关性。研究对象是2001年至2005年在爱知县癌症中心医院就诊的583例组织学诊断的胃癌患者和1636例年龄和性别频率匹配的对照门诊患者。血清anti-H。检测幽门螺杆菌IgG抗体和胃蛋白酶原，分别评价幽门螺杆菌感染情况和胃萎缩情况。比值比（ORs）和95%置信区间（ci）通过logistic模型计算。与胃萎缩对照组相比，相对于ins/ins基因型，ins/del的年龄和性别调整后胃癌的or为1.13 (95% CI: 0.88-1.46)， del/del的or为1.17 (95% CI: 0.79-1.73)， ins/del + del/del的or为1.14 (95% CI: 0.89-1.45)；这些发现都没有统计学意义。TLR2 -196 ~ 174del多态性与幽门螺杆菌血清阳性或胃萎缩均无显著相关性。我们的研究没有重现日本人胃癌风险与TLR2 -196至-174del多态性之间的关联。进一步的研究需要足够数量的研究对象来验证我们的发现。
Recently, the association between gastric cancer risk and a functional polymorphism of Toll-like receptor 2 (TLR2), -196 to -174del, was reported for a Japanese population. This study aimed to confirm the associations of the polymorphism with the risk of gastric cancer, as well as Helicobacter pylori seropositivity and the risk of gastric atrophy in Japanese.The study subjects were 583 histologically diagnosed gastric cancer patients and 1636 age- and sex-frequencymatched control outpatients who visited Aichi Cancer Center Hospital from the years 2001 to 2005. Serum anti-H. pylori IgG antibody and pepsinogens were measured to evaluate H. pylori infection and gastric atrophy, respectively. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by a logistic model.The age- and sex-adjusted ORs of gastric cancer were 1.13 (95% CI: 0.88-1.46) for ins/del, 1.17 (95% CI: 0.79-1.73) for del/del, and 1.14 (95% CI: 0.89-1.45) for ins/del + del/del, relative to the ins/ins genotype compared with gastric atrophy controls; none of these findings were statistically significant. The TLR2 -196 to 174del polymorphism was not significantly associated with either H. pylori seropositivity or gastric atrophy.Our study did not reproduce the association between gastric cancer risk and the TLR2 -196 to -174del polymorphism in Japanese. Further examinations with sufficient numbers of study subjects are required to verify our findings.