CORRELATIONS BETWEEN DEOXYRIBONUCLEIC-ACID STRUCTURAL PARAMETERS AND CALCULATED CIRCULAR-DICHROISM SPECTRA
CORRELATIONS BETWEEN DEOXYRIBONUCLEIC-ACID STRUCTURAL PARAMETERS AND CALCULATED CIRCULAR-DICHROISM SPECTRA
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DOI：
10.1021/bi00504a013
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发表时间：
1981-01-01
期刊：
影响因子：
2.9
通讯作者：
ZHURKIN, VB
中科院分区：
文献类型：
--
作者：
JOHNSON, BB;DAHL, KS;ZHURKIN, VB
计算了T-G-G-C-G-T-A-T-T-C-T及其互补链中68种不同构象碱基的圆二色谱。所有构象都是右手螺旋，包括已发表的模型和能量最小化形式。在275 nm处的圆二色性带的依赖性的检查表明，该带的幅度是螺旋缠绕角和碱基对扭曲的线性函数。圆二色性的大小与碱基对之间的距离、碱基对与螺旋轴的距离或碱基对相对于螺旋轴的倾斜的相关性较差。
Circular dichroism spectra are calculated for 68 different conformations of the bases in the double-stranded sequence of T-G-G-C-G-T-A-T-T-C-T and its complementary strand. All conformations are right-handed helices and include both published models and energy-minimized forms. Examination of the dependence of the circular dichroism band at 275 nm shows that the magnitude of the band is a linear function of both the helix winding angle and the base pair twist. Correlations of the magnitude of the circular dichroism with the distance between base pairs, the distance of the base pairs from the helix axis, or the tilt of the base pair relative to the helix axis are poorer.