Ventilatory response to phasic contraction and passive movement in graded anesthesia.
Ventilatory response to phasic contraction and passive movement in graded anesthesia.
复制标题
分级麻醉中对阶段性收缩和被动运动的通气反应。
DOI：
10.1152/jappl.1986.61.1.91
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发表时间：
1986
影响因子：
3.3
通讯作者：
T. Takishima
中科院分区：
文献类型：
--
作者：
W. Hida;C. Shindoh;Y. Kikuchi;T. Chonan;H. Inoue;H. Sasaki;T. Takishima
在11只氯醛糖-乌拉坦麻醉犬上，观察了不同麻醉深度下后肢肌肉对电诱发收缩（EIC）和被动运动（PM）的反应。通过角膜反射和测量对高碳酸血症的缓解反应来评估麻醉水平。通过电刺激坐骨神经和股神经的外周切断端4-5分钟来诱导肌肉收缩，并且以与EIC期间相同的频率和振幅手动诱导PM。在脊髓完整的狗（n = 7），最初的快速增加分钟通气量（VE）在EIC和PM被发现在轻度和深度麻醉。在EIC期间，VE进一步增加，高于初始上升，但不是PM。两种麻醉水平之间的VE初始快速增加没有差异。EIC期间的稳态反射反应随着麻醉加深而降低，但在PM期间没有这样做。在EIC和PM期间，Rectomy（n = 4）消除了VE的初始快速增加，并在两种麻醉水平下消除了稳态VE对PM的反应。这些结果表明，过渡反射反应是神经介导的肌肉和不受全身麻醉水平。此外，麻醉诱导的呼吸反应降低可能是由于对CO2的反应性降低，而不是吸气运动神经元通路。
The ventilatory response to electrically induced contraction (EIC) and passive movement (PM) of hindlimb muscles at different levels of anesthesia was studied in 11 chloralose-urethan anesthetized dogs with and without rhizotomy. The level of anesthesia was assessed by corneal reflexes and measurements of the ventilatory response to hypercapnia. Muscle contraction was induced by electrically stimulating the peripheral cut ends of the sciatic and femoral nerves for 4-5 min, and PM was induced manually at the same frequency and amplitude as during EIC. In spinal intact dogs (n = 7), initial rapid increases in minute ventilation (VE) during EIC and PM were found in both light and deep anesthesia. Further increases in VE above the initial rise were seen during EIC but not PM. The initial rapid increases in VE did not differ between the two anesthetic levels. The steady-state ventilatory response during EIC decreased as anesthesia deepened but did not do so during PM. Rhizotomy (n = 4) abolished the initial rapid increase in VE during EIC and PM and the steady-state VE response to PM at both anesthetic levels. These results suggest that the transitional ventilatory response is neurally mediated from the muscles and not affected by the level of general anesthesia. Additionally, the anesthesia-induced reduction of ventilatory response may be due to depression of responsiveness to CO2 rather than to the inspiratory motoneuron pathway.