NEURAL MECHANISMS OF AGE-DEPENDENT CHANGES IN AVOIDANCE-BEHAVIOR OF THE SNAIL HELIX-LUCORUM
NEURAL MECHANISMS OF AGE-DEPENDENT CHANGES IN AVOIDANCE-BEHAVIOR OF THE SNAIL HELIX-LUCORUM
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DOI：
10.1016/0306-4522(87)90089-3
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发表时间：
1987-11-01
期刊：
影响因子：
3.3
通讯作者：
BALABAN, PM
中科院分区：
文献类型：
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作者：
ZAKHAROV, IS;BALABAN, PM
为了研究学习和记忆的不同组成部分的出现，我们调查了新生儿和成年陆生蜗牛（Hlucorum L.）的行为，神经生理和组织化学实验的发展变化。在1个月以下的幼螺的行为实验中发现，没有敏化和无法发展回避条件反应。这种行为缺陷的神经机制的调查表明，在幼螺的回避行为的命令神经元的重复神经刺激的穗反应的敏化。同样的动力学的反应幅度，在少年蜗牛，只在成年人中看到选择性损害后，用5，7-二羟色胺治疗的多巴胺能神经元。在孵化后的1个月内，用荧光技术研究的5-羟色胺含量在神经系统中很低。这一结果表明，敏化的情况下，以及无法被厌恶的条件，是有关的5-羟色胺水平，在出生后的发展过程中的蜗牛。
In order to study the emergence of different components of learning and memory, we investigated developmental changes in behavioural, neurophysiological and histochemical experiments in newborn and adult terrestrial snails (Helix lucorum L.). The absence of sensitization and inability to develop avoidance-conditioned reactions were revealed in behavioural experiments in juvenile snails under 1 month old. Investigation of neural mechanisms of this behavioural deficit showed the absence of sensitization in spike reactions to repeated nerve stimulation in command neurons for the avoidance behaviour in juvenile snails. The same dynamics of response amplitude, as in juvenile snails, was seen in adults only after selective impairment of serotonergic neurons by treatment with 5,7-dihydroxytryptamine. During 1 month after hatching, the serotonin content investigated with fluorescence techniques was very low in the nervous system. This result suggests that the absence of sensitization, as well as inability to be aversively conditioned, is related to 5-hydroxytryptamine level, which changes during postnatal development in the snail.