Osteogenesis of 3D printed macro-pore size biphasic calcium phosphate scaffold in rabbit calvaria
Osteogenesis of 3D printed macro-pore size biphasic calcium phosphate scaffold in rabbit calvaria
复制标题
3D打印大孔径双相磷酸钙支架在兔颅骨中的成骨作用
DOI：
10.1177/0885328218825177
复制
发表时间：
2019-04-01
影响因子：
2.9
通讯作者：
Lee, In-Seop
中科院分区：
文献类型：
--
作者：
Liu, Fan;Liu, Yi;Lee, In-Seop
为了研究大孔尺寸的骨支架的成骨作用，采用3D打印技术制备了大孔尺寸精确控制(0.8、1.2和1.6 mm)、相同孔隙率为70%的双相钙磷支架。本研究选取新西兰大白兔8只，每只兔造成4个8 mm大小的颅骨缺损区，放置不同大孔大小的BCP支架。分别于4周和8周取材，通过显微CT和组织学检查评价其成骨能力。所有3D打印的BCP支架在4周和8周时均表现出良好的力学性能，成骨能力均好于对照组。其中，孔径为0.8 mm的支架材料的初始成骨和成熟度最高，总成骨量最高。
To investigate the osteogenesis of macro-pore sized bone scaffolds, biphasic calcium phosphate scaffolds with accurately controlled macro-pore size (0.8, 1.2, and 1.6 mm) and identical porosity of 70% were fabricated by the 3D printing technology. Eight New Zealand rabbits were selected in the present study, while four 8-mm-diameter calvarial defects were created in each rabbit to place BCP scaffolds with different macro-pore size. The harvested specimens of four and eight weeks were used to evaluate the bone forming ability by micro CT and histological examination. All 3D-printed BCP scaffolds exhibited excellent mechanical properties and had better bone-forming ability than the control at both four and eight weeks. Among them, scaffold with 0.8 mm pore size was superior for initial bone formation and maturation, resulting in the highest value of total bone formation.