Antiasthmatic effect of Nigella sativa in airways of asthmatic patients
Antiasthmatic effect of Nigella sativa in airways of asthmatic patients
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DOI：
10.1016/j.phymed.2010.01.002
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发表时间：
2010-08-01
期刊：
影响因子：
7.9
通讯作者：
Takaloo, L.
中科院分区：
文献类型：
--
作者：
Boskabady, M. H.;Mohsenpoor, N.;Takaloo, L.
本研究观察了黑种草子提取物对哮喘患者气道的平喘作用，并以50和100 mg/kg的黑种草子提取物对15例哮喘患者的支气管扩张作用为对照，以6 mg/kg的茶碱为对照。肺功能检查（PFT），包括1秒用力呼气量（FEV 1）、最大呼气流量（PEF）、最大呼气中段流量（MMEF）、75、50和25% FVC时的最大呼气流量在给药前和给药后30、60、90、120、150、1结果表明，在大多数时间间隔内，该提取物引起所有测量的肺功能测试（PFT）的显著增加（p < 0.05至p < 0.001）。然而，由于两种剂量的煮沸提取物引起的FEV 1、MMEF和MEF 50的增加以及由于其较低剂量引起的MEF 75和MEF 25的增加显著低于茶碱（p < 0.05至p < 0.001）。给药后30 min，其作用开始与茶碱相似，150 min后作用开始减弱，与茶碱相似。在给药后30分钟，两种剂量的提取物的作用也显著小于沙丁胺醇的作用（对于所有病例，p < 0.001）。然而，这种植物的煮沸提取物对大多数测量的PFT的影响小于茶碱在使用的浓度。(C)2010年Elsevier GmbH。All rights reserved.
In the present study, the antiasthmatic (bronchodilatory) effect of the boiled extract of Nigella sativa in the airways of asthmatic patients was examined.The bronchodilatory effects of 50 and 100 mg/kg of boiled extract in comparison with 6 mg/kg theophylline were studied on 15 asthmatic patients. Pulmonary function tests (PFTs) including forced expiratory volume in one second (FEV1), peak expiratory flow (PEF), maximal mid expiratory flow (MMEF), maximal expiratory flow at 75, 50 and 25% of the FVC (MEF75, MEF50, and MEF25, respectively) and specific airway conductance (sGaw) were measured before administration and repeated, 30, 60, 90 120, 150, and 180 min after administration of the oral extract and theophylline.The results showed that the extract caused significant increases in all measured pulmonary function tests (PFTs), in most time intervals, (p < 0.05 to p < 0.001). However, the increase in FEV1, MMEF and MEF50 due to both doses of boiled extract and increase in MEF75 and MEF25 due to its lower doses were significantly lower than those of theophylline (p < 0.05 to p < 0.001). The onset of brochodilatory effect of extract was similar to that of theophylline beginning 30 min, and the effect of extract decline after 150 min following administration similar to the effect of theophylline. The effect of both doses of the extract was also significantly less than that of salbutamol at 30 minutes post administration (p < 0.001 for all cases).The results of the present study showed that Nigella sativa has a relatively potent antiasthmatic effect on asthmatic airways. However, the effects of boiled extract of this plant on most measured PFTs was less than those of theophylline at concentrations used. (C) 2010 Elsevier GmbH. All rights reserved.