Does visceral adiposity have an effect on the survival outcomes of the patients with endometrial cancer?
Does visceral adiposity have an effect on the survival outcomes of the patients with endometrial cancer?
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DOI：
10.1111/jog.14560
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发表时间：
2020-11-16
影响因子：
1.6
通讯作者：
Salihoglu, Mehmet Y.
中科院分区：
文献类型：
--
作者：
Celik, Engin;Kizildag Yirgin, Inci;Salihoglu, Mehmet Y.
目的子宫内膜癌是发达国家最常见的女性生殖道癌。有许多危险因素被定义为子宫内膜癌的发展，包括肥胖。目的探讨肥胖对子宫内膜癌患者预后的影响。方法对2009年4月至2017年10月收治的子宫内膜癌患者的临床资料进行回顾性分析。在单层磁共振成像上测量脐部水平的内脏脂肪组织和皮下脂肪组织体积。计算内脏肥胖指数。对患者的临床、人口学、病理学和生存特征进行比较。结果本研究共纳入0.265例内脏肥胖症患者。除年龄、绝经状况、皮下脂肪组织和内脏脂肪组织外，患者的人口学特征、临床特征和肿瘤特征均无显著差异。两组间的无进展生存率和疾病特异性生存率差异无统计学意义(P=0.181)，但两组患者死于子宫内膜癌的比例差异有统计学意义(P=0.024)。不同病种的生存率经对数等级检验有显着性差异。结论内脏脂肪组织是预测子宫内膜癌预后的重要可靠指标。被诊断患有子宫内膜癌的女性应该被告知内脏肥胖症对特定疾病生存的有害影响。
Aim Endometrial cancer is the most common cancer of the female reproductive tract in the developed countries. There are many risk factors defined for the development of endometrial cancer, including obesity. We aimed to evaluate the significance of adiposity on the survival outcomes of the patients with endometrial cancer.Methods The patients diagnosed with endometrial cancer and underwent surgery between April 2009 and October 2017 were retrospectively reviewed. The visceral adipose tissue and subcutaneous adipose tissue volumes were measured at the level of umbilicus on single-slice magnetic resonance imaging. Visceral adiposity index was calculated. Patients were compared regarding their clinical, demographical, pathologic and survival characteristics. Patients divided into low visceral adiposity (0.265, group 2).Results A total of 186 patients were included in this retrospective study. There was no significant difference in terms of the demographical, clinical and tumor characteristics of the patients, except age, menopausal status, subcutaneous adipose tissue and visceral adipose tissue. Although no significant difference in progression-free survival and disease-specific survival was noted between groups (P = 0.181), more patients in group 2 died because of endometrial cancer as statistically significant (P = 0.024). Disease-specific survival showed a significant difference between groups according to the log-rank test.Conclusion Visceral adiposity tissue is a significant and reliable prognostic indicator for endometrial cancer prognosis. Women diagnosed with endometrial cancer should be informed about the deleterious effects of visceral adiposity on disease-specific survival.