Clinical significance and potential mechanism of heat shock factor 1 in acute myeloid leukemia.
Clinical significance and potential mechanism of heat shock factor 1 in acute myeloid leukemia.
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DOI：
10.18632/aging.204267
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发表时间：
2022-09-06
期刊：
影响因子：
5.2
通讯作者：
Xu, Ruirong
中科院分区：
文献类型：
--
作者：
Lyu, Chunyi;Wang, Qian;Yin, Xuewei;Li, Zonghong;Wang, Teng;Wang, Yan;Cui, Siyuan;Liu, Kui;Wang, Zhenzhen;Gao, Chang;Xu, Ruirong
背景：热休克因子1（HSF 1）现在被认为有可能被用作癌症的预后生物标志物。然而，其在急性髓细胞白血病（AML）中的临床意义和潜在功能仍有待进一步研究。研究方法：在这项研究中，通过整合来自数据库的数据，包括癌症基因组图谱（TCGA），基因型-组织表达（GTEx），Vizome，癌细胞系百科全书（CCLE）和基因表达大全（GEO），HSF 1在AML中的表达模式和临床意义进行了研究。应用Linkedomics技术收集AML中HSF 1相关基因。GeneMANIA被用于概述HSF 1相关的功能网络。采用CancerSEA分析、京都基因和基因组百科全书（KEGG）分析和基因集富集分析（GSEA）等方法探讨HSF 1在白血病发病中的作用机制。应用单样本基因集富集分析（ssGSEA）方法探讨HSF 1与AML浸润免疫细胞的相关性。结果：与健康对照组相比，AML中HSF 1表达升高，表明总体生存率较差。HSF 1表达与患者年龄显著相关，与骨髓原始细胞亚组（%）>20的患者生存相关。功能分析表明，HSF 1在AML的转移状态中起作用，并参与炎症相关通路和生物学过程。HSF 1表达与NK细胞和T细胞的免疫浸润密切相关。结论：HSF 1在AML发病的分子网络中起重要作用，有望成为AML预后的生物标志物。
Background: Heat shock factor 1 (HSF1) is now considered to have the potential to be used as a prognostic biomarker in cancers. However, its clinical significance and potential function in acute myeloid leukemia (AML) remain underexplored. Methods: In this study, the expression pattern and clinical significance of HSF1 in AML were examined by integrating data from databases including The Cancer Genome Atlas (TCGA), The Genotype–Tissue Expression (GTEx), Vizome, Cancer Cell Line Encyclopedia (CCLE) and Gene Expression Omnibus (GEO). Linkedomics was applied to collect HSF1–related genes in AML. GeneMANIA was applied to outline HSF1–related functional networks. CancerSEA analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis and Gene Set Enrichment Analysis (GSEA) were performed to mine the potential mechanism of HSF1 in leukemogenesis. Single–sample Gene Set Enrichment Analysis (ssGSEA) was applied to explore the correlation between HSF1 and infiltrating immune cells in AML. Results: HSF1 expression was elevated in AML compared to healthy controls and indicate a poor overall survival. HSF1 expression was significantly correlated with patients age, associated with patient survival in subgroup of bone marrow blasts (%) >20. Functional analyses indicated that HSF1 plays a role in the metastatic status of AML, and is involved in inflammation–related pathways and biological processes. HSF1 expression was significantly correlated with the immune infiltration of nature killer cells and T cell population. Conclusion: HSF1 plays a vital role in the molecular network of AML pathogenesis, and has the potential to be a biomarker for prognosis prediction.
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影响因子：
64.8
作者：
Muench DE;Olsson A;Ferchen K;Pham G;Serafin RA;Chutipongtanate S;Dwivedi P;Song B;Hay S;Chetal K;Trump-Durbin LR;Mookerjee-Basu J;Zhang K;Yu JC;Lutzko C;Myers KC;Nazor KL;Greis KD;Kappes DJ;Way SS;Salomonis N;Grimes HL
通讯作者：
Grimes HL
影响因子：
3.7
作者：
Lacourt, Tamara E.;Kavelaars, Annemieke;Heijnen, Cobi J.
通讯作者：
Heijnen, Cobi J.
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影响因子：
4.3
作者：
Pan, Xiaoyan;Lin, Jian;Liu, Shuwen
通讯作者：
Liu, Shuwen
影响因子：
6.4
作者：
Frezzato, Federica;Raggi, Flavia;Trentin, Livio
通讯作者：
Trentin, Livio
影响因子：
64.5
作者：
Mendillo ML;Santagata S;Koeva M;Bell GW;Hu R;Tamimi RM;Fraenkel E;Ince TA;Whitesell L;Lindquist S
通讯作者：
Lindquist S