Corticotropin-releasing factor concentrations exhibit an apparent diurnal rhythm in hypothalamic and extrahypothalamic brain regions: differential sensitivity to corticosterone.
Corticotropin-releasing factor concentrations exhibit an apparent diurnal rhythm in hypothalamic and extrahypothalamic brain regions: differential sensitivity to corticosterone.
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促肾上腺皮质激素释放因子浓度在下丘脑和下丘脑外大脑区域表现出明显的昼夜节律：对皮质酮的敏感性不同。
DOI：
10.1159/000125655
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发表时间：
1990
影响因子：
4.1
通讯作者：
Nemeroff,CB
中科院分区：
文献类型：
--
作者：
Owens,MJ;Bartolome,J;Schanberg,SM;Nemeroff,CB
促肾上腺皮质激素释放因子（CRF）的脑区域浓度在许多区域表现出显著差异，这取决于一天中牺牲大鼠的时间。与09.00 h处死的动物相比，15.30 h时的CRF浓度在正中隆起、下丘脑-正中隆起、视前区/视交叉上核、终纹床核、中隔、额/顶叶皮质、小脑、扣带皮质、蓝斑和孤束核中均升高。通过渗透性微型泵连续补充7天皮质酮的动物，要么下午CRF浓度（中隆起、扣带皮层和蓝斑）没有上升，要么下午CRF浓度（下丘脑减去中隆起）的增加明显减弱。在9时死亡的大鼠中，皮质酮降低了中央隆起的CRF浓度。慢性皮质酮暴露不影响下丘脑外任何脑区的CRF浓度。这些结果表明，下丘脑和下丘脑外脑区的许多含有CRF的神经元的活动可能会发生昼夜变化，CRF浓度的变化证明了这一点。此外，长期补充皮质酮可以改变这些变化，特别是下丘脑内分泌的变化。
Regional brain concentrations of corticotropin-releasing factor (CRF) exhibited marked differences in a number of regions depending upon the time of day rats were sacrificed. When compared with animals killed at 09.00 h, CRF concentrations at 15.30 h were elevated in the median eminence, hypothalamus minus median eminence, preoptic area/suprachiasmatic nucleus, bed nucleus of the stria terminalis, septum, frontal/parietal cortex, cerebellum, cingulate cortex, locus ceruleus and the nucleus of the solitary tract. Animals that received 7 days of continuous corticosterone supplementation via osmotic minipump either did not exhibit an afternoon rise in CRF concentrations (median eminence, cingulate cortex and locus ceruleus) or exhibited significantly attenuated afternoon increases in CRF concentrations (hypothalamus minus median eminence). In rats killed at 09.00 h, corticosterone reduced CRF concentrations in the median eminence. Chronic corticosterone exposure did not affect CRF concentrations in any of the extrahypothalamic brain regions studied in rats killed at 09.00 h. These results suggest that a number of CRF-containing neurons in both hypothalamic and extrahypothalamic brain regions presumably undergo diurnal changes in their activity as evidenced by changes in CRF concentrations. Furthermore, chronic corticosterone supplementation can alter these changes, particularly those in the endocrine hypothalamus.