Spectrum of esophageal disorders in children with chest pain.
Spectrum of esophageal disorders in children with chest pain.
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胸痛儿童食管疾病的谱系。
DOI：
10.1007/bf01296420
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发表时间：
1992
影响因子：
3.1
通讯作者：
Newman,LJ
中科院分区：
文献类型：
--
作者：
Glassman,MS;Medow,MS;Berezin,S;Newman,LJ
对83例胸痛患儿进行食管测压和食管胃镜检查。47例（57%）食管组织学正常，运动正常（组I）。食管炎和正常的运动被证明在15个儿童（组II），正常的食管组织学和食管动力障碍13（组III），和食管炎和运动异常8（组IV）。弥漫性食管痉挛和贲门失弛缓症是最常见的运动障碍（分别为7例和4例）。四个患者组之间的症状的存在和持续时间、年龄和性别没有差异。H2受体阻滞剂治疗6个月后，15例II组患者中有12例无症状，而食管动力异常的患者中有5例对食管扩张或钙通道阻滞剂、H2受体拮抗剂和/或促动力剂治疗有反应（P<0.01）。这些数据表明，即使没有其他胃肠相关症状，对胸痛儿童的评估也应包括食管动力学检查和食管镜检查，虽然食管炎治疗可导致症状缓解，但动力障碍相对难治。
The charts of 83 children with chest pain who underwent esophageal manometry followed by esophagogastroscopy were reviewed. Forty-seven (57%) had normal esophageal histology and normal motility (group I). Esophagitis and normal motility were demonstrated in 15 children (group II), normal esophageal histology and esophageal dysmotility in 13 (group III), and both esophagitis and abnormal motility in 8 (group IV). Diffuse esophageal spasm and achalasia were the most common motility disorders identified (in seven and four patients, respectively). The presence and duration of symptoms, the age, and the gender were not different among the four patient groups. After six months of H2-receptor blockade, 12 of 15 group II patients were asymptomatic, whereas a significantly smaller percentage (five of 18) of patients with abnormal esophageal motility responded to esophageal dilation or treatment with calcium channel blockade, H2-receptor antagonist, and/or prokinetic agents (P<0.01). These data suggest that the evaluation of children with chest pain should include esophageal motility testing and esophagoscopy, even in the absence of other gastrointestinal-associated symptoms, and that while treatment of esophagitis results in resolution of symptoms, motility disorders were relatively refractory to therapy.