Throwing while looking through prisms .1. Focal olivocerebellar lesions impair adaptation
Throwing while looking through prisms .1. Focal olivocerebellar lesions impair adaptation
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DOI：
10.1093/brain/119.4.1183
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发表时间：
1996-08-01
期刊：
影响因子：
14.5
通讯作者：
Thach, WT
中科院分区：
文献类型：
--
作者：
Martin, TA;Keating, JG;Thach, WT
正常人类受试者和橄榄小脑系统损伤的患者戴着楔形棱镜眼镜向视觉目标投掷粘土球。正常受试者最初朝棱镜弯曲凝视的方向投掷，但经过反复投掷以适应击中目标。患有全身性小脑萎缩、下橄榄肥大或同侧下脚、对侧基底脑桥或同侧小脑中脚小脑后下动脉分布局灶性梗塞的患者，棱镜适应受损或缺失。小脑后下动脉分布区梗死的患者通常具有受损或缺乏适应能力，但很少或没有共济失调。相比之下，小脑上动脉分布或小脑丘脑受损的患者通常患有共济失调，但仍保留适应能力。这些结果表明，来自对侧下橄榄核通过同侧小脑下脚的攀爬纤维、来自对侧脑桥小脑核通过同侧小脑中脚的杂乱纤维以及小脑后下动脉区域皮层对于这种适应至关重要。齿丘脑投射和小脑上动脉区域皮质对于这种适应不是必需的。
Normal human subjects and patients with lesions of the olivocerebellar system threw balls of clay at a visual target while wearing wedge prism spectacles. Normal subjects initially threw in the direction of prism-bent gaze, but with repeated throws adapted to hit the target. Patients with generalized cerebellar atrophy, inferior olive hypertrophy, or focal infarcts in the distribution of the posterior inferior cerebellar artery in the ipsilateral inferior peduncle, in the contralateral basal pons or in the ipsilateral middle cerebellar peduncle had impaired or absent prism adaptation. Patients with infarcts in the distribution of the posterior inferior cerebellar artery usually had impaired or absent adaptation but little or no ataxia. By contrast patients with damage in the distribution of the superior cerebellar artery or in cerebellar thalamus usually had ataxia but preserved adaptation. These results implicate climbing fibres from the contralateral inferior olive via the ipsilateral inferior cerebellar peduncle, messy fibres from the contralateral pontocerebellar nuclei via the ipsilateral middle cerebellar peduncle, and posterior inferior cerebellar artery territory cortex as being critical for this adaptation. The dentatothalamic projection and the superior cerebellar artery territory cortex are not necessary for this adaptation.