Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population
Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population
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DOI：
10.1016/j.bbrc.2007.10.180
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发表时间：
2008-01-18
影响因子：
3.1
通讯作者：
Kato, Takeo
中科院分区：
文献类型：
--
作者：
Daimon, Makoto;Sato, Hidenori;Kato, Takeo
5个SNPs的关联使用Takahata研究的群体（n（M/W）：2930），检测2型糖尿病患者11类磷酸肌醇3-激酶γ-亚基（PIK 3C 2G）基因的SNPs 1 -5：A-5468 G、A-3333 G、C-1794 T、C437 T和T9148 C（1328/1602）;年龄：63.3 +/- 10.2岁），一项日本社区研究。SNP与HbAlc水平的定量关联研究显示SNP 2和4的显著关联（分别为p = 0.018和0.004）。通过多元逻辑回归分析的SNP 4与糖尿病的病例对照关联研究显示SNP的TT基因型与独立于年龄、性别和BMI的优势比为2.21（p = 0.001）显著相关。在NGT受试者中，SNP 4高危基因型组的血清空腹胰岛素水平显著低于其他基因型组（TT、TC和CC，分别为4.9 +/- 2.6、5.4 +/- 3.0和5.6 +/- 3.4 μ U/ml; p = 0.029）。(c)2007爱思唯尔公司All rights reserved.
The associations of five SNPs (SNPsl-5: A-5468G, A-3333G, C-1794T, C437T and T9148C) of the class 11 phosphoinositide 3-kinase gamma-subunit (PIK3C2G) gene with type 2 diabetes were examined using a population of the Takahata Study (n (M/W): 2930 (1328/1602); age: 63.3 +/- 10.2 years), a Japanese community-based study. Quantitative association study of the SNPs with HbAlc levels showed significant association for SNPs 2 and 4 (p = 0.018 and 0.004, respectively). A case-control association study of SNP 4 with diabetes by multiple logistic regression analysis showed a significant association of the genotype TT of the SNP with an odds ratio of 2.21 (p = 0.001) independently of age, gender and BMI. In the NGT subjects, serum fasting insulin levels in the at-risk genotype group of SNP 4 were significantly lower than those in the others (TT, TC, and CC, 4.9 +/- 2.6, 5.4 +/- 3.0, and 5.6 +/- 3.4 mu U/ml, respectively; p = 0.029). (c) 2007 Elsevier Inc. All rights reserved.