Calcium-dependent control of temporal processing in an auditory interneuron: a computational analysis.
Calcium-dependent control of temporal processing in an auditory interneuron: a computational analysis.
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DOI：
10.1007/s00359-010-0547-z
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
Farris HE
中科院分区：
文献类型：
--
作者：
Ponnath A;Farris HE
蟋蟀对声振幅调制的敏感性在物种之间不同，并取决于载波频率（例如，呼叫歌曲与蝙蝠超声波乐队）。使用计算工具，我们探讨了选择性注意的Ca2+依赖机制如何导致幅度调制敏感性的差异。对于omega神经元1（ON1），选择性注意由Ca2+依赖性反馈介导：[Ca2+]内部随着兴奋而增加，激活Ca2+依赖性后超极化电流。我们认为，钙离子的去除率和后超极化电流的大小可以决定ON1的时间调制传递函数（TMTF）。这是测试使用基于电导的模拟校准到体内的反应。该模型表明，参数值，模拟单脉冲的反应是足够的模拟调制刺激的反应：没有特殊的调制敏感的机制是必要的，因为高和低通部分的TMTF是由于钙依赖性尖峰频率适应和突触后电位抑制，分别。此外，两个生物物理参数的变化足以产生不同带宽的TMTF，像不同物种中那样移动幅度调制灵敏度，并响应于不同的载波频率。因此，计算验证了后超极化电流的大小和Ca 2+去除率可以影响幅度调制灵敏度的假设。
Sensitivity to acoustic amplitude modulation in crickets differs between species and depends on carrier frequency (e.g., calling song vs. bat-ultrasound bands). Using computational tools, we explore how Ca2+-dependent mechanisms underlying selective attention can contribute to such differences in amplitude modulation sensitivity. For omega neuron 1 (ON1), selective attention is mediated by Ca2+-dependent feedback: [Ca2+]internal increases with excitation, activating a Ca2+-dependent after-hyperpolarizing current. We propose that Ca2+ removal rate and the size of the after-hyperpolarizing current can determine ON1’s temporal modulation transfer function (TMTF). This is tested using a conductance-based simulation calibrated to responses in vivo. The model shows that parameter values that simulate responses to single pulses are sufficient in simulating responses to modulated stimuli: no special modulation-sensitive mechanisms are necessary, as high and low-pass portions of the TMTF are due to Ca2+-dependent spike frequency adaptation and post-synaptic potential depression, respectively. Furthermore, variance in the two biophysical parameters is sufficient to produce TMTFs of varying bandwidth, shifting amplitude modulation sensitivity like that in different species and in response to different carrier frequencies. Thus, the hypothesis that the size of after-hyperpolarizing current and the rate of Ca2+ removal can affect amplitude modulation sensitivity is computationally validated.
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DOI：
10.1085/jgp.105.1.49
发表时间：
1995-01
期刊：
The Journal of general physiology
影响因子：
--
作者：
Art JJ;Wu YC;Fettiplace R
通讯作者：
Fettiplace R
影响因子：
2.5
作者：
EGELHAAF, M;BORST, A
通讯作者：
BORST, A
影响因子：
5.3
作者：
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通讯作者：
Maler, L
影响因子：
5.5
作者：
Chen, Qing-Hui;Toney, Glenn M.
通讯作者：
Toney, Glenn M.
影响因子：
3.4
作者：
Engel, J;Schultens, HA;Schild, D
通讯作者：
Schild, D