Clinical Outcome Measure Crosswalks in Alzheimer's Disease: A Systematic Review.
Clinical Outcome Measure Crosswalks in Alzheimer's Disease: A Systematic Review.
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DOI：
10.3233/jad-210060
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发表时间：
2021
影响因子：
4
通讯作者：
Hunt, Adriana
中科院分区：
文献类型：
--
作者：
Hlavka, Jakub P.;Kinoshita, Andrew T.;Fang, Samantha;Hunt, Adriana
在对现有和新出现的痴呆症治疗方法的结果、疾病进展和成本效益进行建模的研究中，一个关键挑战是缺乏转换标准来转换多个测量尺度上的分数。痴呆症的临床状态通常表现在认知、功能和行为领域。我们在这三个领域对同行评议的痴呆症测量方法进行了系统回顾。我们系统地回顾了已发表的关于用于测量阿尔茨海默氏症和相关痴呆患者认知、功能或行为结果的量表之间的人行横道的文献。这项搜索是在PubMed进行的，通过滚雪球和痴呆症建模人员的专家输入确定了额外的人行横道。在评价的文章中，通过PubMed搜索确定了2334篇文章，842篇文章来自前后引用滚雪球，另外8篇文章通过专家输入进行推荐。31篇论文有资格入选，列出了74个独特的人行横道。其中，62个(83.8%)位于认知域的端点之间，12个(16.2%)位于功能域的端点之间或本质上是混合的。在仅限于认知领域的人行横道中，大多数涉及简易精神状态检查(MMSE)(37个人行横道)或蒙特利尔认知评估(MoCA)及其变体(25个人行横道)。在16个人行横道中，MMSE被直接与MoCA或MoCA变体进行比较。现有的痴呆症测量之间的交叉路口主要集中在有限的结果测量选择上，特别是MMSE和MoCA。人行横道在功能域中很少存在，并且没有发现单独用于行为测量的人行横道。
A key challenge in studies that model outcomes, disease progression, and cost-effectiveness of existing and emerging dementia treatments is the lack of conversion criteria to translate, or ‘crosswalk’, scores on multiple measurement scales. Clinical status in dementia is commonly characterized in the cognitive, functional, and behavioral domains. We conducted a systematic review of peer-reviewed dementia measure crosswalks in the three domains. We systematically reviewed published literature for crosswalks between scales used to measure cognitive, functional, or behavioral outcomes in Alzheimer’s and related dementias. The search was conducted in PubMed, and additional crosswalks were identified through snowballing and expert input from dementia modelers. Of the reviewed articles, 2,334 were identified through a PubMed search, 842 articles were sourced from backward and forward citation snowballing, and 8 additional articles were recommended through expert input. 31 papers were eligible for inclusion, listing 74 unique crosswalks. Of those, 62 (83.8%) were between endpoints of the cognitive domain and 12 (16.2%) were either between endpoints of the functional domain or were hybrid in nature. Among crosswalks exclusively in the cognitive domain, a majority involved the Mini-Mental State Examination (MMSE) (37 crosswalks) or the Montreal Cognitive Assessment (MoCA) and its variants (25 crosswalks). MMSE was directly compared to MoCA or MoCA variants in 16 crosswalks. Existing crosswalks between measures of dementia focus largely on a limited selection of outcome measures, particularly MMSE and MoCA. Few crosswalks exist in the functional domain, and no crosswalks were identified for solely behavioral measures.