Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold
Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold
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DOI：
10.1002/anie.200901134
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Roelfes, Gerard
中科院分区：
文献类型：
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作者：
Coquiere, David;Bos, Jeffrey;Roelfes, Gerard
网站创建：通过引入能够与铜离子配位的氨基酸，将一个新的活性位点嫁接到牛胰多肽上，已经产生了对映选择性人工金属酶。该混合催化剂在水中的Diels-Alder和Michael加成反应中给出了良好的对映选择性（参见方案），并显示出非常高的底物选择性。
Site creation: Enantioselective artificial metalloenzymes have been created by grafting a new active site onto bovine pancreatic polypeptide through the introduction of an amino acid capable of coordinating a copper(II) ion. This hybrid catalyst gave good enantioselectivities in the Diels–Alder and Michael addition reactions in water (see scheme) and displayed a very high substrate selectivity.