"Connectomic surgery": diffusion tensor imaging (DTI) tractography as a targeting modality for surgical modulation of neural networks
"Connectomic surgery": diffusion tensor imaging (DTI) tractography as a targeting modality for surgical modulation of neural networks
复制标题
DOI：
10.3389/fnint.2012.00015
复制
发表时间：
2012-01-01
影响因子：
3.5
通讯作者：
Henderson, Jaimie M.
中科院分区：
文献类型：
--
作者：
Henderson, Jaimie M.
脑深部电刺激（DBS）被用于治疗越来越多的神经系统疾病。直到最近，DBS一直被认为主要通过抑制局部神经元活动起作用，基本上产生功能性损伤。许多研究表明，DBS具有广泛的网络效应介导的白色物质途径。连接组学的新科学旨在绘制健康和疾病大脑区域之间的连接。专门针对表现出病理连接的通路进行DBS可以极大地扩展治疗脑部疾病的可能性。这篇简短的评论检查了用于这些网络可视化的大脑成像的当前状态，并描述了如何使用DBS来恢复病理状态下的正常连接。
Deep brain stimulation (DBS) is being used to treat a growing number of neurological disorders. Until recently, DBS has been thought to act mainly by suppressing local neuronal activity, essentially producing a functional lesion. Numerous studies are now demonstrating that DBS has widespread network effects mediated by white matter pathways. The new science of connectomics aims to map the connectivity between brain regions in health and disease. Targeting DBS specifically to pathways which exhibit pathological connectivity could greatly expand the possibilities for treating brain diseases. This brief review examines the current state of brain imaging for visualization of these networks and describes how DBS might be used to restore normal connectivity in pathological states.