The role of T cells in pemphigus vulgaris and bullous pemphigoid
The role of T cells in pemphigus vulgaris and bullous pemphigoid
复制标题
T细胞在寻常型天疱疮和大疱性类天疱疮中的作用
DOI：
10.1016/j.autrev.2020.102661
复制
发表时间：
2020-11-01
影响因子：
13.6
通讯作者：
Wang, Gang
中科院分区：
文献类型：
--
作者：
Fang, Hui;Li, Qingyang;Wang, Gang
寻常型天疱疮(PV)和大疱性类天疱疮(BP)是自身抗体介导的疾病，临床表现为皮肤和/或粘膜水泡和侵蚀。免疫失衡和抗体生成是自身免疫性大疱病的重要病理基础。近年来，大量研究表明，在自身免疫中起关键作用的T细胞亚群表现出一系列的异常，并在PV和BP中驱动免疫发病机制和皮肤炎症。辅助性T细胞(Th)1通过干扰素-γ介导炎症或免疫反应，Th2来源的细胞因子，如IL-4，可促进B细胞增殖、抗体产生和免疫球蛋白类转换。Th17细胞促进炎症反应和皮肤损伤，而调节性T细胞抑制自身反应性CD4(+)T细胞的激活，帮助控制炎症。T滤泡辅助细胞与B细胞相互作用，促进自身抗体的产生。本文就PV和BP的免疫特点作一综述，重点介绍在PV和BP发病机制中T细胞亚群的异常，如Th1细胞、Th2细胞、Th17细胞、调节性T细胞、T滤泡辅助细胞、CD8(+)T细胞、Gamma-Delta T细胞和驻留记忆T细胞。提高对自身免疫性皮肤病患者T细胞亚群生物学和免疫学功能的了解，将为识别这些复杂疾病的治疗靶点提供独特的机会。
Pemphigus vulgaris (PV) and bullous pemphigoid (BP) are autoantibody-mediated diseases clinically characterized by blisters and erosions of skin and/or mucous membranes. Immune imbalance and antibody generation are the key pathologies of autoimmune bullous diseases. Recently, a large number of studies have shown that T cell subsets, which are critical players in autoimmunity, exhibit a range of abnormalities and drive immunopathogenesis and skin inflammation in PV and BP. T helper (Th)1 cells mediate pro-inflammatory or immune responses through IFN-gamma and Th2-derived cytokines, such as IL-4, can promote B cell proliferation, antibody production and immunoglobulin class-switching. Th17 cells promote inflammatory response and skin damage, while regulatory T cells suppress autoreactive CD4(+) T cell activation and help control inflammation. T follicular helper cells cross-talk with B cells and facilitate autoantibody production. In this review, we discuss the immune features of PV and BP, with a focus on the aberrations in T cell subsets, such as Th1 cells, Th2 cells, Th17 cells, regulatory T cells, T follicular helper cells, CD8(+) T cells, gamma delta T cells and resident memory T cells in the pathogenesis of PV and BP. Improved understanding of biological and immunological functions of T cell subsets in patients with autoimmune skin disorders will offer unique opportunities for the recognition of treatment targets for these complex diseases.