Remyelination in multiple sclerosis
Remyelination in multiple sclerosis
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DOI：
10.1016/s0022-510x(02)00191-0
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发表时间：
2003-02-15
影响因子：
4.4
通讯作者：
Stadelmann, C
中科院分区：
文献类型：
--
作者：
Brück, W;Kuhlmann, T;Stadelmann, C
多发性硬化症(MS)病变中的再髓鞘形成已经在几项研究中被描述。这取决于髓鞘少突胶质细胞的存在以及这些髓鞘细胞和轴突之间的功能性相互作用。磁共振成像或光谱学中的再髓鞘形成的成像信号尚未定义。现就复髓多发性硬化症病变的形态表现、与少突胶质细胞病理的相关性以及复髓的可能的影像标志物进行综述。(C)2002 Elsevier Science B.V.保留所有权利。
Remyelination in multiple sclerosis (MS) lesions has been described in several studies. It depends on the presence of myelinating oligodendrocytes and a functional interaction between these myelinating cells and axons. The imaging signal of remyelination in magnetic resonance imaging or spectroscopy is not yet defined. The present review will focus on the morphological appearance of remyelinating MS lesions, their correlation with oligodendrocyte pathology, and possible markers for remyelination in imaging. (C) 2002 Elsevier Science B.V. All rights reserved.