Estrogen receptor gene polymorphism and bone mineral density in postmenopausal Chinese women
Estrogen receptor gene polymorphism and bone mineral density in postmenopausal Chinese women
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DOI：
10.1016/s8756-3282(01)00481-1
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发表时间：
2001-07-01
期刊：
影响因子：
4.1
通讯作者：
Woo, J
中科院分区：
文献类型：
--
作者：
Lau, EMC;Young, RP;Woo, J
本文检测了454例55 ~ 79岁绝经后中国妇女雌激素受体基因（ERG） PvuII和XbaI限制性片段长度多态性（RFLPs）及其与骨密度（BMD）的关系。RFLPs用P或P （pvii）和X或X （XbaI）表示，大写字母表示不存在限制性位点，小写字母表示存在限制性位点。PP、PP和PP基因型之间骨密度无显著差异。然而，XX基因型的女性脊柱骨密度明显高于XX或XX基因型的女性。BMI差异的大小为老年女性骨密度标准差（SD）的80%，绝经后女性骨密度标准差（SD）的40%。PvuII基因型与XbaI基因型对BMI的影响无统计学意义。我们得出结论，绝经后的中国女性，纯合子的XX基因型比其他人的骨密度略高。然而，骨密度的差异很小，不太可能有任何临床意义。ERG不是香港中国女性骨密度的主要决定因素。(C) 2001年Elsevier Science Inc.版权所有。
PvuII and XbaI restriction fragment length polymorphisms (RFLPs) for the estrogen receptor gene (ERG) and its relation to bone mineral density (BMD) were examined in 454 postmenopausal Chinese women, aged 55-79 years. The RFLPs were represented as P or p (PvuII) and X or x (XbaI), with capital letters signifying the absence of and small letters the presence of restriction sites. There was no significant difference in BMD between the PP, Pp, and pp genotypes. However, women of the XX genotype had significantly higher BMD at the spine than women of the Xx or xx genotype. The magnitude of the difference in BMI) was 80% of a standard deviation (SD) for BMD in elderly women and 40% of a SD in postmenopausal women. There was no statistically significant interaction between the PvuII genotype and the XbaI genotype in determining BMI). We conclude that postmenopausal Chinese women who were homozygous for the XX genotype had slightly higher BMD than the others. However, the difference in BMD was small and was unlikely to have any clinical significance. The ERG is not a major determinant of BMD in Chinese women in Hong Kong. (C) 2001 by Elsevier Science Inc. All rights reserved.