Cortisol dysregulation in school teachers in relation to burnout, vital exhaustion, and effort-reward-imbalance
Cortisol dysregulation in school teachers in relation to burnout, vital exhaustion, and effort-reward-imbalance
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DOI：
10.1016/j.biopsycho.2008.01.006
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发表时间：
2008-04-01
影响因子：
2.6
通讯作者：
Kudielka, Brigitte M.
中科院分区：
文献类型：
--
作者：
Bellingrath, Silja;Weigl, Tobias;Kudielka, Brigitte M.
我们分析了学校教师(N=135；25~63岁；平均年龄46.1~9.20岁)的职业倦怠、生命衰竭或与工作相关的慢性应激是否与下丘脑-垂体-肾上腺(HPA)轴调节异常有关。参与者收集了7个唾液样本(醒来后0、30、45和60分钟，上午11点，下午3点，晚上8点)。分别于2个工作日、1个休闲日和用药前给予0.25 mg地塞米松(极小剂量地塞米松抑制试验)，评估基础皮质醇日变化和HPA轴负反馈敏感性。没有发现基础皮质醇活动与倦怠(Maslach职业倦怠量表、教师职业倦怠量表)、生命衰竭(Appels生命衰竭问卷)或Siegrist的努力-回报-不平衡模型的任何组成部分之间存在关联。然而，地塞米松治疗后，更高的倦怠、生命衰竭和更低的奖赏与更强的皮质醇抑制显著相关，这表明HPA轴负反馈敏感性改变。尽管所有教师都在工作，而且健康状况良好，但职业倦怠/疲惫以及ERI模型的某些方面似乎与微妙的调节失调有关，表现为HPA轴负反馈增加，尽管在皮质醇基础日曲线中没有。(C)2008爱思唯尔B.V.保留所有权利。
We analyzed whether burnout and vital exhaustion or job-related chronic stress is associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation in school teachers (N = 135; 25-63 years; mean age 46.1 9.20 years). Participants collected seven saliva samples (0, 30, 45, and 60 min after awakening, 11 a.m., 3 p.m., 8 p.m.) on 2 working days, 1 leisure day, and after pre-medication with 0.25 mg dexamethasone (very low-dose dexamethasone suppression test) to assess basal cortisol day profiles and HPA axis negative feedback sensitivity. No associations were found between basal cortisol activity and burnout (Maslach burnout inventory, teacher burnout scale), vital exhaustion (Appels vital exhaustion questionnaire), or any component of Siegrist's effort-reward-imbalance model. However, after dexamethasone higher burnout and vital exhaustion and lower reward were significantly related to stronger cortisol suppression, pointing to altered HPA axis negative feedback sensitivity. Though, all teachers were working and in a good health status, burnout/exhaustion as well as facets of the ERI model appear to be associated with subtle dysregulation, manifested as heightened HPA axis negative feedback although not in basal cortisol day profiles. (c) 2008 Elsevier B.V. All rights reserved.