Feasibility of transrib focused ultrasound thermal ablation for liver tumors using a spherically curved 2D array: A numerical study
Feasibility of transrib focused ultrasound thermal ablation for liver tumors using a spherically curved 2D array: A numerical study
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DOI：
10.1118/1.2759888
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发表时间：
2007-09-01
期刊：
影响因子：
3.8
通讯作者：
Lin, Win-Li
中科院分区：
文献类型：
--
作者：
Liu, Hao-Li;Chang, Hsu;Lin, Win-Li
聚焦超声热消融治疗肝癌和其他肝脏肿瘤具有良好的临床效果。然而，主要的缺点之一是肋对超声波能量的高吸收，在许多情况下需要部分切除肋。本研究对球面超声相控阵用于经肋肝肿瘤热消融的可行性进行了数值研究。为了解决肋骨过热问题，提出了一种基于反馈解剖医学成像的独立阵列元件激活方案，该方案关闭被肋骨阻挡的传感器元件。数值结果表明，所提出的治疗计划策略能够在保持目标位置能量的同时有效降低肋骨吸收的比能量，既减少了肋骨过热问题，又增加了在完整肋骨下治疗目标病变的可能性。分析还表明，靶位和超声频率在治疗中起关键作用。具有不同特征的患者也进行了测试，以显示所提出策略的普遍性。所提出的治疗计划策略也为临床行经肋超声肝肿瘤热消融前评估治疗效果提供了有用的信息。(c) 2007年美国医学物理学家协会。
The use of focused ultrasound thermal ablation to treat hepatocarcinorna and other liver tumors produces promising clinical results. However, one of the major drawbacks is the high absorption of ultrasonic energy by the rib, making partial rib removal necessary in many cases. This study numerically investigated the feasibility of using a spherical ultrasound phased array for transrib liver-tumor thermal ablation. An independently array-element activitation scheme, which switches off the transducer elements obstructed by the ribs based on feedback anatomical medical imaging, was proposed to reduce the rib-overheating problem. The numerical results showed that the proposed treatment planning strategy can effectively reduce the specific energy absorbed by the rib while maintaining the energy at the target position, which both reduces the rib-overheating problem and increases the possibility of treating a target lesion under an intact rib. The analysis also demonstrated that the target position and the ultrasound frequency play key roles in the treatment. Patients with diverse characteristics were also tested to show the generality of the proposed strategy. The proposed treatment planning strategy also provides useful information for evaluating the treatment effectiveness prior to clinically performing transrib ultrasound liver-tumor thermal ablation. (c) 2007 American Association of Physicists in Medicine.