Reproductive aging: theoretical perspectives, mechanisms, nonhuman models, and health correlates
Reproductive aging: theoretical perspectives, mechanisms, nonhuman models, and health correlates
复制标题
DOI：
10.1111/j.1749-6632.2010.05700.x
复制
发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Wise, Phyllis
中科院分区：
文献类型：
--
作者：
Haaga, John;O'Connor, Kathleen;Wise, Phyllis
每365.2421999天或多或少地球绕太阳沿着椭圆轨道自转、公转、摆动和进动。我们这些在旅途中幸存下来的人又老了一岁：我们老了一个太阳年。有些年份我们似乎比其他年份老得快;有些人似乎比其他人老得快;有些系统似乎比其他系统老得快。当我们开始成熟，达到中年，并成为老年人，生殖变化是最显着的衰老标志之一，特别是在妇女中。如果有的话，我们能从生殖衰老中了解更多的衰老过程吗？我们繁殖后的生存是否有助于我们的健康，或者这只是一个偶然事件，是对其他特征的选择的结果？我们的见解和研究能否转化为更好的临床实践？我们探讨生殖老化与广角多学科的透镜，我们用来集中在四个明确的领域：理论观点，机制，非人类模型，和健康相关。我们提出了今后工作的方向。"
Every 365.2421999 days-more or less-the earth rotates, revolves, wobbles, and precesses along an elliptical path around the sun. Those of us who survive the journey are a year older: we have aged one solar year. Some years we seem to age faster than other years; some people seem to age faster than other people; some systems seem to age faster than other systems. As we begin to mature, reach our middle years, and become elderly, reproductive changes are among the markers of aging that are most notable, particularly among women. What-if anything-can we learn about more general processes of aging from reproductive aging? Does our postreproductive survival contribute to our fitness, or is it just a chance event, a result of selection on other characteristics? Can our insights and research be translated into improved clinical practice? We explore reproductive aging with a wide-angle multidisciplinary lens that we use to focus on four articulating areas: theoretical perspectives, mechanisms, nonhuman models, and health correlates. We propose directions for future work."