Digital Microfluidics: A New Paradigm for Radiochemistry.
Digital Microfluidics: A New Paradigm for Radiochemistry.
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DOI：
10.2310/7290.2015.00030
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发表时间：
2015-12-05
影响因子：
2.8
通讯作者：
van Dam RM
中科院分区：
文献类型：
--
作者：
Keng PY;van Dam RM
新兴的数字微流体技术正在开辟在微升规模下进行放射化学的可能性，以生产用氟-18或其他同位素标记的正电子发射断层扫描（PET）示踪剂。在这种体积规模下工作不仅降低了试剂成本，而且通过减少稳定同位素的污染来提高比活度（SA）。这项技术可以提供一种实用的手段，以常规制备高SA示踪剂的应用，如神经成像，并可以使它有可能常规实现高SA使用合成策略，如同位素交换。试剂液滴通过电子方式控制，提供高可靠性、紧凑的控制系统，并通过单芯片设计实现多种合成。紧凑的尺寸可以使得能够开发不需要热室的自屏蔽合成器。本文综述了该技术的研究进展及其在PET示踪剂合成中的应用。
The emerging technology of digital microfluidics is opening up the possibility to perform radiochemistry at the microliter scale to produce tracers for positron emission tomography (PET) labeled with fluorine-18 or other isotopes. Working at this volume scale not only reduces reagent costs, but also improves specific activity (SA) by reduction of contamination by the stable isotope. This technology could provide a practical means to routinely prepare high SA tracers for applications such as neuroimaging, and could make it possible to routinely achieve high SA using synthesis strategies such as isotopic exchange. Reagent droplets are controlled electronically, providing high reliability, a compact control system, and flexibility for diverse syntheses with a single chip design. The compact size may enable the development of a self-shielded synthesizer that does not require a hot cell. This article reviews the progress of this technology and its application to the synthesis of PET tracers.