Modeling household transmission of American trypanosomiasis
Modeling household transmission of American trypanosomiasis
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DOI：
10.1126/science.1060638
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发表时间：
2001-07-27
期刊：
影响因子：
56.9
通讯作者：
Gürtler, RE
中科院分区：
文献类型：
--
作者：
Cohen, JE;Gürtler, RE
美洲锥虫病，或称恰加斯病，由原虫寄生虫克氏锥虫引起，通过吸血的三甲虫传播，是一种慢性、经常致命的感染，在拉丁美洲很常见。既没有足够的药物，也没有疫苗。一个根据阿根廷西北部三个村庄的详细家庭数据进行校准的数学模型显示，住户可以通过将家畜，特别是受感染的狗排除在卧室之外，从等待和天花板上移除可能的虫子庇护所，以及使用国内使用的杀虫剂，来极大地降低人类感染的风险。低成本、当地可行的环境管理与间歇使用杀虫剂相结合，可以可持续地控制克鲁兹旋毛虫在阿根廷农村和可能其他地方向人类的传播。
American trypanosomiasis, or Chagas disease, caused by the protozoan parasite Trypanosoma cruzi and transmitted by blood-feeding triatomine bugs, is a chronic, frequently fatal infection that is common in Latin America. Neither adequate drugs nor a vaccine is available. A mathematical model calibrated to detailed household data from three villages in northwest Argentina shows that householders could greatly reduce the risk of human infection by excluding domestic animals, especially infected dogs, from bedrooms; removing potential refuges for bugs from waits and ceilings; and using domestically applied insecticides. Low-cost, locally practicable environmental management combined with intermittent use of insecticides can sustainably control transmission of T. cruzi to humans in rural Argentina and probably elsewhere.