Cellular dopamine is increased following exposure to a factor derived from immortalized striatal neurons [corrected].

Cellular dopamine is increased following exposure to a factor derived from immortalized striatal neurons [corrected].
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接触来自永生化纹状体神经元的因子后,细胞多巴胺会增加[已校正]。

DOI:
10.1016/s0304-3940(00)01589-5
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发表时间:
2000
影响因子:
2.5
通讯作者:
Won,L
Won,L
中科院分区:
医学4区
文献类型:
--
作者:
Heller,A;Freeney,A;Hessefort,S;Villereal,M;Won,L

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A factor obtained from an immortalized hybrid monoclonal cell line (X61) of striatal origin is capable of increasing the dopamine content of hybrid, monoclonal cells expressing a dopaminergic phenotype (MN9D) and of aggregate cultures containing primary dopaminergic neurons. The factor is a protein smaller than 100 kDa and appears to be different than a number of other trophic agents with effects on the dopaminergic neuron. The effect on dopamine content appears to be specific to centrally-derived neuronal elements; the protein having no effect on the dopamine content of PC12 cells. Given that parkinsonian symptoms are only apparent following degeneration of a substantial portion of the mesencephalic dopaminergic cell population, activity capable of increasing dopamine content of the surviving cells may represent an interesting candidate therapeutic agent.
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