State-dependent sensory gating in olfactory cortex
State-dependent sensory gating in olfactory cortex
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DOI：
10.1016/j.neuron.2005.02.025
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发表时间：
2005-04-21
期刊：
影响因子：
16.2
通讯作者：
Mori, K
中科院分区：
文献类型：
--
作者：
Murakami, M;Kashiwadani, H;Mori, K
感觉系统表现出行为状态依赖的信息流门控，这在很大程度上取决于丘脑。在这里，我们研究了状态依赖性门控是否发生在缺乏丘脑中继的中央嗅觉通路中。聚氨酯麻醉大鼠脑电在两种状态之间周期性交替：以大波和慢波为特征的慢波状态（SWS）和以快波为特征的快波状态（FWS）。来自嗅觉皮层神经元的单单元记录显示，在FWS期间，它们对适当的气味有强烈的spike反应，而在SWS期间，它们只显示出微弱的反应。在大多数嗅觉皮层神经元中观察到气味诱发反应的状态依赖性变化，但仅在嗅球神经元中观察到一小部分。这些发现表明，在嗅觉皮层中，气味信息的一种强大的状态依赖门控与其他感觉系统的门控同步工作。他们认为，在嗅觉皮层中，信号处理模式的转换依赖于状态。
Sensory systems show behavioral state-dependent gating of information flow that largely depends on the thalamus. Here we examined whether the statedependent gating occurs in the central olfactory pathway that lacks a thalamic relay. In urethane-anesthetized rats, neocortical EEG showed a periodical alternation between two states: a slow-wave state (SWS) characterized by large and slow waves and a fast-wave state (FWS) characterized by faster waves. Single-unit recordings from olfactory cortex neurons showed robust spike responses to adequate odorants during FWS, whereas they showed only weak responses during SWS. The state-dependent change in odorant-evoked responses was observed in a majority of olfactory cortex neurons, but in only a small percentage of olfactory bulb neurons. These findings demonstrate a powerful state-dependent gating of odor information in the olfactory cortex that works in synchrony with the gating of other sensory systems. They suggest a state-dependent switchover of signal processing modes in the olfactory cortex.