Cell adhesion molecules in neural histogenesis.
Cell adhesion molecules in neural histogenesis.
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神经组织发生中的细胞粘附分子。
DOI：
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发表时间：
1986
影响因子：
18.2
通讯作者：
G. Edelman
中科院分区：
文献类型：
--
作者：
G. Edelman
除了进化变化本身，神经网络的变异性有三个主要来源：躯体发育序列，它负责网络的形成和神经解剖学；突触的化学和结构变化（尤指与神经递质和通道有关的变化）；电的变化取决于细胞的内在代谢和外部信号。这些进程以明确的发展顺序出现。然而，同样清楚的是，这些过程中没有一个是完全独立于其他过程的，尽管它们的相对贡献随时间而变化。虽然在过去的三十年里，人们已经对神经递质和电活动进行了大量的研究，但直到最近，人们才有可能研究神经网络形成的恒定和变化的分子基础，纤维束的绘制，以及神经和肌肉最早接触的建立。这种分子分析的关键要素之一是发展了一系列一致的测定（4,12,13,32），这些测定明确地建立了细胞粘附分子（CAMs）的分离、结构和功能表征标准。在此之前，这种分子存在的证据是稀疏和不令人信服的，但自从它的应用以来，至少有三个不同的cam被分离和描述（1,4,7,8,12,20,25,26,28,31,32,34）。根据他们的描述，以前识别的功能未知的分子（20,26,31）被确定为cam。特定的cam在神经元-神经元、神经元-肌肉和神经元-胶质结合中起着关键作用，并且从神经系统发育的最早阶段开始，每种cam都以特有的动态模式和时空分布出现在神经组织中（12）。
Aside from evolutionary change itself, there are three main sources of variabil ity in neural networks: the somatic developmental sequence, which is responsi ble for network formation and neuroanatomy; the chemical and structural variation at synapses (particularly that related to neurotransmitters and chan nels); and the electrical variation that depends both upon intrinsic cellular metabolism and external signals. These processes emerge in a clear-cut order of development. It is just as clear, however, that none of these processes is fully independent of the others, although their relative contributions vary in time. While much has been done to study neurotransmitters and electrical activity in the last three decades, only recently has it become possible to study the molecular bases of constancy and variation in network formation, fiber tract mapping, and the establishment of the earliest contacts of nerve and muscle. One of the key elements in this molecular analysis has been the development of a concerted series of assays (4, 12, 13, 32) that unequivocally establish criteria for the isolation and structural and functional characterization of cell adhesion molecules (CAMs). Prior to this approach, the evidence for the existence of such molecules was sparse and unconvincing, but since its applica tion at least three different CAMs have been isolated and described (1,4, 7, 8, 12, 20, 25, 26, 28, 31, 32, 34). On the basis of their description, previously recognized molecules whose functions had been unknown (20, 26, 31) were identified as CAMs. Particular CAMs have pivotal roles in neuron-neuron, neuron-muscle, and neuron-glial binding, and from the earliest stages in the development of the nervous system, each appears in neural tissues in characteristic dynamic patterns and spatiotemporal distributions (12).
神经系统诱导、组织发生和围产期发育过程中细胞粘附的调节。
影响因子：
13.9
作者：
Edelman,GM
通讯作者：
Edelman,GM
鸡神经细胞粘附分子 (N-CAM) cDNA 克隆的分离。
DOI：
10.1073/pnas.81.17.5584
发表时间：
1984
影响因子：
11.1
作者：
Murray,BA;Hemperly,JJ;Gallin,WJ;MacGregor,JS;Edelman,GM;Cunningham,BA
通讯作者：
Cunningham,BA
神经细胞粘附分子的结合机制。
影响因子：
--
作者：
Hoffman,S;Edelman,GM
通讯作者：
Edelman,GM